The impact of certain flavourings and preservatives on the survivability of larvae of nematodes of Ruminantia
AbstractAnnualy, helminthic diseases are one of the causes of economic losses in agriculture. Ruminantia are most often observed to be infected with nematodes of the gastrointestinal tract, including Strongyloides papillosus and the representatives of the Strongylida order. Identifying factors which could cause a decrease in the level of infection of agricultural animals with helminthiases would allow stock-raising facilities to regularly achieve high quality dairy and meat production in sufficient quantity. On the basis of this study, we determined the impact of flavourings and source materials approved for use in and on foods (isoamyl alcohol, isoamyl acetate, raspberry ketone, trilon B, methylparaben) on the survivability of larvae of Strongyloides papillosus and Haemonchus contortus, parasitic nematodes of Ruminantia animals. Among these substances, the lowest efficiency against the nematode larvae was found in isoamyl alcohol, isoamyl acetate and trilon B. A stronger effect was caused by methylparaben (for L3S. papillosus LD50 = 0.67 ± 0.04%, L1 and L2S. papillosus – LD50 = 0.0038 ± 0.0008%, L3H. contortus – LD50 = 0.89 ± 0.15%). Minimum efficient dosage of the solutions was 10 g/l. Significant antihelminthic properties were manifested by raspberry ketone (for L3S. papillosus LD50 = 1.00 ± 0.72%, L1 and L2S. papillosus – LD50 = 0.07 ± 0.06%, L3H. contortus – LD50 = 0.39 ± 0.26%). The results show that there is considerable potential for further studies on the antiparasitic properties of these substances against nematodes in the conditions of farming enterprises and agricultural complexes.
Belletti, N., Kamdem, S. S., Tabanelli, G., Lanciotti, R., & Gardini, F. (2010). Modeling of combined effects of citral, linalool and β-pinene used against Saccharomyces cerevisiae in citrus-based beverages subjected to a mild heat treatment. International Journal of Food Microbiology, 136(3), 283–289.
Belkind, B. A., Shammo, B., Dickenson, R., Rehberger, L. A., & Heiman, D. F. (2013). Cinnamaldehyde and diallyl disulfide formulations and methods of use. U.S. Patent No. 20130018107. Libertyville, IL, USA.
Biffa, D., Jobre, Y., & Chakka, H. (2006). Ovine helminthosis, a major health constraint to productivity of sheep in Ethiopia. Animal Health Research Reviews, 7(1–2), 107–118.
Bhutto, B., Phullan, M. S., Rind, R., & Soomro, A. H. (2002). Prevalence of gastro-intestinal helminths in Buffalo Calves. Journal of Biological Sciences, 2(1), 43–45.
Boyko, O. O., Zazharska, N. M., & Brygadyrenko, V. V. (2016). The influence of the extent of infestation by helminths upon changes in body weight of sheep in Ukraine. Visnyk of Dnipropetrovsk University. Biology, Ecology, 24(1), 3–7.
Boyko, A. A., & Brygadyrenko, V. V. (2017). Changes in the viability of Strongyloides ransomi larvae (Nematoda, Rhabditida) under the influence of synthetic flavourings. Regulatory Mechanisms in Biosystems, 8(1), 36–40.
Boyko, A. A., & Brygadyrenko, V. V. (2017). Changes in the viability of the eggs of Ascaris suum under the influence of flavourings and source materials approved for use in and on foods. Biosystems Diversity, 25(2), 162–166.
Burke, J. M., Wells, A., Casey, P., & Kaplan, R. M. (2009). Herbal dewormer fails to control gastrointestinal nematodes in goats. Veterinary Parasitology, 160(1–2), 168–170.
Chalquest, R. R. (2002). Materials and methods for killing nematodes and nematode eggs. U.S. Patent No. 0016330. La Jolla, CA, USA.
Cheng, S.-S., Liu, J.-Y., Huang, C.-G., Hsui, Y.-R., Chen, W.-J., & Chang, S.-T. (2009). Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species. Bioresource Technology, 100(1), 457–464.
Chhetri, B., Ali, N., & Setzer, W. (2015). A survey of chemical compositions and biological activities of Yemeni aromatic medicinal plants. Medicines, 2(2), 67–92.
Chiang, L.-C., Ng, L.-T., Cheng, P.-W., Chiang, W., & Lin, C.-C. (2005). Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and Experimental Pharmacology and Physiology, 32(10), 811–816.
Cringoli, G., Veneziano, V., Jackson, F., Vercruysse, J., Greer, A. W., Fedele, V., Mezzino, L., & Rinaldi, L. (2008). Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles. Veterinary Parasitology, 156(3–4), 340–345.
Faye, D., Leak, S., Nouala, S., Fall, A., Losson, B., & Geerts, S. (2003). Effects of gastrointestinal helminth infections and plane of nutrition on the health and productivity of F1 (West African Dwarf × Sahelian) goat crosses in The Gambia. Small Ruminant Research, 50(1–2), 153–161.
Gonzalez-Coloma, A., Diaz, C. E., Julio, L. F., Burilo, J., & Fe Andres, M. (Eds.). (2017). A case study of MAPs production, uses and commercialization Artemisia absinthium var. candia L: Extract characterization and valorization. Frontiers in Horticulture, 1, 163–196.
Gopalakrishnan, S., Chitra, T. A., Aruna, A., & Chenthilnathan, A. (2012). Development of RP-HPLC method for the simultaneous estimation of ambroxol hydrochloride, cetirizine hydrochloride and antimicrobial preservatives in combined dosage form. Der Pharma Chemica, 4(3), 1003–1015.
Ishiwatari, S., Suzuki, T., Hitomi, T., Yoshino, T., Matsukuma, S., & Tsuji, T. (2006). Effects of methyl paraben on skin keratinocytes. Journal of Applied Toxicology, 27(1), 1–9.
Fahlbusch, K.-G., Hammerschmidt, F.-J., Panten, J., Pickenhagen, W., Schatkowski, D., Bauer, K., Garbe, D., & Surburg, H. (2002). Flavors and fragrances. Ullmann's encyclopedia of industrial chemistry. Wiley-VCH, Weinheim.
Kloosterman, A., Ploeger, H. W., Pieke, E. J., Lam, T. J. G. M., & Verhoeff, J. (1996). The value of bulk milk ELISA Ostertagia antibody titres as indicators of milk production response to anthelmintic treatment in the dry period. Veterinary Parasitology, 64(3), 197–205.
Knoblauch, C., & Fry, K. (2011). Non-toxic insecticide. U.S. Patent No. 7956092. Edmonton, Alberta, CA, USA.
Kromidas, L., Perrier, E., Flanagan, J., Rivero, R., & Bonnet, I. (2006). Release of antimicrobial actives from microcapsules by the action of axillary bacteria. International Journal of Cosmetic Science, 28(2), 103–108.
Lai, Y.-W., Campbell, L. T., Wilkins, M. R., Pang, C. N. I., Chen, S., & Carter, D. A. (2016). Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus. International Journal of Antimicrobial Agents, 48(4), 388–394.
Lee, E.-J., Kim, J.-R., Choi, D.-R., & Ahn, Y.-J. (2008). Toxicity of cassia and cinnamon oil compounds and cinnamaldehyde-related compounds to Sitophilus oryzae (Coleoptera: Curculionidae). Journal of Economic Entomology, 101(6), 1960–1966.
Lee, H. S. (2004). p-Anisaldehyde: Acaricidal component of Pimpinella anisum seed oil against the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus. Planta Medica, 70(3), 279–281.
Lide, D. R. (1998). Handbook of chemistry and physics (87 ed.). CRC Press, Boca Raton, FL.
Lindqvist, Å., Ljungström, B.-L., Nilsson, O., & Waller, P. (2001). The dynamics, prevalence and impact of nematode infections in organically raised sheep in Sweden. Acta Veterinaria Scandinavica, 42(3), 377–389.
Lu, C. D., Gangyi, X., & Kawas, J. R. (2010). Organic goat production, processsing and marketing: Opportunities, challenges and outlook. Small Ruminant Research, 89(2–3), 102–109.
Manu, D. K. (2016). Antimicrobial activity of cinnamaldehyde or geraniol alone or combined with high pressure processing to destroy Escherichia coli O157: H7 and Salmonella enterica in juices. Iowa State University, Ames, Iowa.
Meyer, B. K., Ni, A., Hu, B., & Shi, L. (2007). Antimicrobial preservative use in parenteral products: Past and present. Journal of Pharmaceutical Sciences, 96(12), 3155–3167.
Na, Y. E., Kim, S.-I., Bang, H.-S., Kim, B.-S., & Ahn, Y.-J. (2011). Fumigant toxicity of cassia and cinnamon oils and cinnamaldehyde and structurally related compounds to Dermanyssus gallinae (Acari: Dermanyssidae). Veterinary Parasitology, 178(3–4), 324–329.
Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013 (Blue Book). (2014). The Royal Society of Chemistry, Cambridge.
Pedersen, M., & Woldum, H. (2011). Oil-in-water formulation of avermectins. U.S. Patent No. 0009350. Lemvig, DK, USA.
Ploeger, H. W., Kloosterman, A., Bargeman, G., Wuijckhuise, L., & van den Brink, R. (1990). Milk yield increase after anthelmintic treatment of dairy cattle related some parameters estimating helminth infection. Veterinary Parasitology, 35(1–2), 103–116.
Posey, R., Culbertson, E. C., & Westermeier, J. C. (2005). Clear barrier coating and coated film. U.S. Patent No. 6911255. Greer, SC, USA.
Rahmann, G., & Seip, H. (2006). Alternative strategies to prevent and control endoparasite diseases in organic sheep and goat farming systems. Ressortforschung für den Ökologischen Landbau, 298, 49–90.
Rebbeck, C., Hammond, R., Wong, J., Nair, L., Raghavan, N., Hepler, D., Campbell, W., & Lynn, R. (2006). Solid-phase extraction and HPLC analysis of methylparaben and propylparaben in a concentrated antibiotic suspension. Drug Development and Industrial Pharmacy, 32(9), 1095–1102.
Ribeiro, P. R., de Castro, R. D., & Fernandez, L. G. (2016). Chemical constituents of the oilseed crop Ricinus communis and their pharmacological activities: A review. Industrial Crops and Products, 91, 358–376.
Shapiro, S., Giertsen, E., & Guggenheim, B. (2002). An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses. Caries Research, 36(2), 93–100.
Soni, M. G., Taylor, S. L., Greenberg, N. A., & Burdock, G. A. (2002). Evaluation of the health aspects of methyl paraben: A review of the published literature. Food and Chemical Toxicology, 40(10), 1335–1373.
Sato, K., Krist, S., & Buchbauer, G. (2006). Antimicrobial effect of trans-cinnamaldehyde, (−)-perillaldehyde, (−)-citronellal, citral, eugenol and carvacrol on airborne microbes using an airwasher. Biological and Pharmaceutical Bulletin, 29(11), 2292–2294.
Shen, F., Xing, M., Liu, L., Tang, X., Wang, W., Wang, X., Wu, X., Wang, X., Wang, X., Wang, G., Zhang, J., Li, L., Zhang, J., & Yu, L. (2012). Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro. Parasitology Research, 110(4), 1321–1326.
Si, W., Ni, X., Gong, J., Yu, H., Tsao, R., Han, Y., & Chambers, J. R. (2009). Antimicrobial activity of essential oils and structurally related synthetic food additives towards Clostridium perfringens. Journal of Applied Microbiology, 106(1), 213–220.
Somolinos, M., Garcia, D., Pagan, R., & Mackey, B. (2008). Relationship between sublethal injury and microbial inactivation by the combination of high hydrostatic pressure and citral or tert-butyl hydroquinone. Applied and Environmental Microbiology, 74(24), 7570–7577.
Taylor, W. S. (2009). Flea control method. U.S. Patent No. 0036407. Wilmington, DE, USA.
Ullah, I., Khan, A. L., Ali, L., Khan, A. R., Waqas, M., Hussain, J., Lee, I. J., & Shin, J.-H. (2015). Benzaldehyde as an insecticidal, antimicrobial, and antioxidant compound produced by Photorhabdus temperata M1021. Journal of Microbiology, 53(2), 127–133.
Veneziano, V., Rubino, R., Fedele, V., Rinaldi, L., Santaniello, M., Schioppi, M., Cascone, C., Pizzillo, M., & Cringoli, G. (2004). The effects of five anthelmintic treatment regimes on milk production in goats naturally infected by gastrointestinal nematodes. South African Journal of Animal Science, 34, 238–240.
Vercruysse, J., & Claerebout, E. (2001). Treatment vs non-treatment of helminth infections in cattle: Defining the threshold. Veterinary Parasitology, 98(1–3), 195–214.
Van der Voort, M., Charlier, J., Lauwers, L., Vercruysse, J., Van Huylenbroeck, G., & Van Meensel, J. (2013). Conceptual framework for analysing farm-specific economic effects of helminth infections in ruminants and control strategies. Preventive Veterinary Medicine, 109(3–4), 228–235.
Zajac, A. M., & Conboy, G. A. (Eds.). (2011). Veterinary clinical parasitology. 8th ed. John Wiley and Sons, London.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons «Attribution» 4.0 License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.