Influence of high-bromine poultry products on clinical-biochemical blood parameters of white rats

  • Y. M. Koreneva Institute of Experimental and Clinical Veterinary Medicine
  • O. L. Orobchenko Institute of Experimental and Clinical Veterinary Medicine
  • M. Y. Romanko Institute of Experimental and Clinical Veterinary Medicine
  • N. G. Malova V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine
  • R. M. Sachuk Rivne State University for the Humanities
  • B. V. Gutyj Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies
  • M. L. Radzykhovskyi National University of Life and Environmental Sciences of Ukraine
Keywords: eggs; meat; hepatotoxycity; hypothyreosis; aminotransferases; alkaline phosphatase; thyroid hormones

Abstract

Bromine content in fodder and water for laying chickens in Ukraine gradually increasing, thereby accumulating in the poultry production (eggs and meat): according to the data, intake of bromine with chicken eggs in 2020 has almost doubled, compared with 2016. Taking into account the ability of bromine to accumulate and the scales of consumption of poultry products, it is relevant to study the effects of high bromine concentration on the level of thyroid hormones and clinical-biochemical parameters of blood of white rats. At the laboratory of Toxicological Monitoring of the National Scientific Center the Institute of Experimental and Clinical Veterinary Medicine and the Department of Experimental Pharmacology and Toxicology of the State Institution V.Y. Danylevskyi Institute of Problems of Endocrine Pathology of the National Academy of Medical Sciences of Ukraine, we carried out studies on white outbred male rats (n = 144). The diet of experimental groups was supplemented with eggs and meat containing high bromine concentration. We determined increase in the coefficients of liver weight and decrease in the coefficients of lung weight in the experimental rats. Moreover, we determined changes in the biochemical blood profile, in particular: after egg consumption, there occurred 20.0–22.0% decrease in the enzymatic activity of alanine aminotransferase, 23.0–48.4% in the activity of aspartate aminotransferase, and on average 21.3% decrease in alkaline phosphatase, compared with the control; after meat consumption, the level of total proteins decreased by 8.6%, glucose by 12.2–14.5%, also there were 13.8–18.5% decrease in the activity of alanine aminotransferase and 12.1–83.0% increase in the activity of aspartate aminotransferase on the 28th day, and 23.2–35.3% decrease in the activity of alkaline phosphatase. After the intake of both poultry products, the blood serum of animals was observed to have decrease in the level of overall thyroxine and overall triiodothyronine (1.3 times on average, depending on the period of study). The results of the studies can help in prediction and timely alleviation of the negative impact of poultry products with high bromine content on the human organism.

References

Addis, D. R., Lambert, J. A., Ford, D. A., Jilling, T., & Matalon, S. (2021). Halogen gas exposure: Toxic effects on the parturient. Toxicology Mechanisms and Methods, 31(4), 272–287.

Bailey, R. L., West, K. P., & Black, R. E. (2015). The epidemiology of global micronutrient deficiencies. Annals of Nutrition and Metabolism, 66(2), 22–33.

Barysheva, E. S. (2018). Experimental simulation of the effects of essential and toxic trace elements on thyroid function. Bulletin of Experimental Biology and Medicine, 164(4), 439–441.

Bomko, V., Kropyvka, Y., Bomko, L., Chernyuk, S., Kropyvka, S., & Gutyj, B. (2018). Effect of mixed ligand complexes of zinc, manganese, and cobalt on the manganese balance in high-yielding cows during first 100-days lactation. Ukrainian Journal of Ecology, 8(1), 420–425.

Costa, M. M., Pestana, J. M., Osório, D., Alfaia, C. M., Martins, C. F., Mourato, M., Gueifão, S., Rego, A. M., Coelho, I., Coelho, D., Lemos. J. P. C., Fontes, C. M. G. A., Lordelo, M. M., & Prates, J. A. M. (2022). Effect of dietary Laminaria digitata with carbohydrases on broiler production performance and meat quality, lipid profile, and mineral composition. Animals, 12(8), 1007.

Dhouibi, R., Affes, H., Ben Salem, M., Charfi, S., Marekchi, R., Hammami, S., Zeghal, K., & Ksouda, K. (2021). Protective effect of Urtica dioica in induced neurobehavioral changes, nephrotoxicity and hepatotoxicity after chronic exposure to potassium bromate in rats. Environmental Pollution, 287, 117657.

Du Toit, J., & Casey, N. (2011). Effect of bromine and iodine in drinking water on production parameters of broilers. South African Journal of Animal Science, 40(4), 301–310.

Du Toit, J., & Casey, N. H. (2012). Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens. Livestock Science, 144, 269–274.

Elmadfa, I., & Meyer, A. L. (2019). The role of the status of selected micronutrients in shaping the immune function. Endocrine, Metabolic and Immune Disorders – Drug Targets, 19(8), 1100–1115.

Fabri, A. Z. (2005). Ekolohohihienichni aspekty poshyrennia endemichnoho zoba v riznykh bioheokhimichnykh zonakh Zakarpattia [Ecological and hygienic aspects of the spread of endemic goiter in various biogeochemical zones of Zakarpattya]. Endocrinology, 10, 41–50 (in Ukrainian).

Gutyj, B. V., Ostapyuk, A. Y., Sobolev, O. I., Vishchur, V. J., Gubash, O. P., Kurtyak, B. M., Kovalskyi, Y. V., Darmohray, L. M., Hunchak, A. V., Tsisaryk, O. Y., Shcherbatyy, A. R., Farionik, T. V., Savchuk, L. B., Palyadichuk, O. R., & Hrymak, K. (2019). Cadmium burden impact on morphological and biochemical blood indicators of poultry. Ukrainian Journal of Ecology, 9(1), 235–239.

Gutyj, B., Ostapiuk, A., Kachmar, N., Stadnytska, O., Sobolev, O., Binksevych, V., Petryshak, R., Petryshak, O., Kulyaba, O., Naumyuk, A., Nedashkivsky, V., Nedashkivska, N., Magrelo, N., Golodyuk, I., Nazaruk, N., & Binkevych, O. (2019). The effect of cadmium loading on protein synthesis function and functional state of laying hens’ liver. Ukrainian Journal of Ecology, 9(3), 222–226.

Gutyj, B., Stybel, V., Darmohray, L., Lavryshyn, Y., Turko, I., Hachak, Y., Shcherbatyy, A., Bushueva, I., Parchenko, V., Kaplaushenko, A., & Krushelnytska, O. (2017). Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load. Ukrainian Journal of Ecology, 7(4), 589–596.

Jiang, X., Shi, P., Jiang, L., Qiu, J., Xu, B., Pan, Y., & Zhou, Q. (2022). In vivo toxicity evaluations of halophenolic disinfection byproducts in drinking water: A multi-omics analysis of toxic mechanisms. Water Research, 218, 118431.

Jones, B. A., Tinsley, I. J., Wilson, G., & Lowry, R. R. (1983). Toxicology of brominated fatty acids: Metabolite concentration and heart and liver changes. Lipids, 18(4), 327–334.

Karpenko, Y., Hunchak, Y., Gutyj, B., Hunchak, A., Parchenko, M., & Parchenko, V. (2022). Advanced research for physico-chemical properties and parameters of toxicity piperazinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate. ScienceRise: Pharmaceutical Science, 36, 18–25.

Kohlmeier, M. (2003). Bromine. In: Kohlmeier, M. (Ed.). Nutrient metabolism. Academic Press. Pp. 753–756.

Koreneva, Y. (2020). The toxicokinetics of bromine in the body of laying hens under conditions of subchronic administration of sodium bromide diet. Scientific Journal of Veterinary Medicine, 2, 140–149.

Kotsiumbas, I. Y. (2005). Doklinichni doslidzhennia veterynarnykh likarskykh zasobiv [Preclinical studies of veterinary medicinal products]. Triada Plius, Lviv (in Ukrainian).

Kozeniecki, M., Ludke, R., Kerner, J., & Patterson, B. (2020). Micronutrients in liver disease: Roles, risk factors for deficiency, and recommendations for supplementation. Nutrition in Clinical Practice, 35(1), 50–62.

Kutsan, O. T., Orobchenko, O. L., & Kochergin, Y. A. (2014). Toksyko-biohimichna kharakterystyka neorganichnykh elementiv ta zastosuvannia rentgenofluorestsentnogo analizu u veterynarnij medytsyni [Toxic-biochemical characteristic of inorganic elements and application of X-ray fluorescence analysis in veterinary medicine]. Planet Print, Kharkiv (in Ukrainian).

Kutsan, О. Т., Orobchenko, O. L., & Koreneva, Y. M. (2020). The quality and safety of eggs obtained from laying hens after their experimental poisoning with sodium bromide. Journal for Veterinary Medicine, Biotechnology and Biosafety, 6, 25–30.

Lam, A., Vetal, N., Matalon, S., & Aggarwal, S. (2016). Role of heme in bromine-induced lung injury. Annals of the New York Academy of Sciences, 1374(1), 105–110.

Magee, P. J., & McCann, M. T. (2019). Micronutrient deficiencies: Current issues. Proceedings of the Nutrition Society, 78(2), 147–149.

Marsan, E. S., & Bayse, C. A. (2020). A halogen bonding perspective on iodothyronine deiodinase activity. Molecules, 25(6), 1328.

Martyshuk, T. V., Gutyj, B. V., Zhelavskyi, M. M., Midyk, S. V., Fedorchenko, A. M., Todoriuk, V. B., Nahirniak, T. B., Kisera, Y. V., Sus, H. V., Chemerys, V. A., Levkivska, N. D., & Iglitskej, I. I. (2020). Effect of Butaselmevit-Plus on the immune system of piglets during and after weaning. Ukrainian Journal of Ecology, 10(2), 347–352.

Martyshuk, T., Gutyj, B., Vyshchur, O., Paterega, I., Kushnir, V., Bigdan, O., & Tkachenko, N. (2022). Study of acute and chronic toxicity of “Butaselmevit” on laboratory animals. Archives of Pharmacy Practice, 13(3), 70–75.

Nalyvayko, L., Rodionova, K., Pankova, S., Shomina, N., Katerynych, O., & Khimych, M. (2021). Comparative characteristics of eggs of chickens of domestic and foreign selection in their diverse age. Potravinarstvo Slovak Journal of Food Sciences, 15, 245–253.

Nimalaratne, C., & Wu, J. (2015). Hen egg as an antioxidant food commodity: A review. Nutrients, 7, 8274–8293.

Orobchenko, O. L., Kutsan, О. Т., & Koreneva, Y. M. (2018). Toksykokinetyka bromu v orhanizmi bilykh shchuriv-samtsiv za umov odnorazovoho peroralnoho vvedennia natriiu bromidu [The toxicokinetics of bromine in the body of white male rats under conditions of sodium bromide single-dose oral using]. Bulletin of the Sumy National Agrarian University, Veterinary Medicine, 42, 177–185 (in Ukrainian).

Orobchenko, O., Koreneva, Y., Paliy, A., Rodionova, K., Korenev, M., Kravchenko, N., Pavlichenko, O., Tkachuk, S., Nechyporenko, O., & Nazarenko, S. (2022). Bromine in chicken eggs, feed, and water from different regions of Ukraine. Potravinarstvo Slovak Journal of Food Sciences, 16, 42–54.

Pavelka, S. (2004). Metabolism of bromide and its interference with the metabolism of iodine. Physiological Research, 53(1), 81–90.

Pavelka, S., Babický, A., Lener, J., & Vobecký, M. (2002). Impact of high bromide intake in the rat dam on iodine transfer to the sucklings. Food and Chemical Toxicology, 40, 1041–1045.

Rauws, A. G. (1983). Pharmacokinetics of bromide ion – an overview. Food and Chemical Toxicology, 21(4), 379–382.

Razanova, O., Yaremchuk, O., Gutyj, B., Farionik, T., & Novgorodska, N. (2022). Dynamics of some mineral elements content in the muscle, bone and liver of quails under the apimin influence. Scientific Horizons, 25(5), 22–29.

Sameliuk, Y., Kaplaushenko, A., Nedorezanıuk, N., Ostretsova, L., Diakova, F., & Gutyj, B. (2022). Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole. Hacettepe University Journal of the Faculty of Pharmacy, 42(3), 175–186.

Simmonds, R. C. (2017). Chapter 4. Bioethics and animal use in programs of research, teaching, and testing. In: Weichbrod, R. H., Thompson, G. A. H., Norton, J. N. (Eds.). Management of animal care and use programs in research, education, and testing. 2nd edition. CRC Press, Taylor & Francis, Boca Raton. Pp. 1–28.

Slivinska, L. G., Shcherbatyy, A. R., Lukashchuk, B. O., Zinko, H. O., Gutyj, B. V., Lychuk, M. G., Chernushkin, B. O., Leno, M. I., Prystupa, O. I., Leskiv, K. Y., Slepokura, O. I., Sobolev, O. I., Shkromada, O. I., Kysterna, O. S., & Мusiienko, O. V. (2019). Correction of indicators of erythrocytopoesis and microelement blood levels in cows under conditions of technogenic pollution. Ukrainian Journal of Ecology, 9(2), 127–135.

Sobolev, O. I., Gutyj, B. V., Darmohray, L. M., Sobolievа, S. V., Ivanina, V. V., Kuzmenko, O. A., Karkach, P. M., Fesenko, V. F., Bilkevych, V. V., Mashkin, Y. O., Trofymchuk, A. M., Stavetska, R. V., Tkachenko, S. V., Babenko, O. I., Klopenko, N. I., & Chernyuk, S. V. (2019). Lithium in the natural environment and its migration in the trophic chain. Ukrainian Journal of Ecology, 9(2), 195–203.

Sobolev, O. I., Gutyj, B. V., Sobolievа, S. V., Borshch, О. O., Nedashkivsky, V. M., Kachan, L. M., Karkach, P. M., Nedashkivska, N. V., Poroshinska, O. А., Stovbetska, L. S., Emelyanenko, A. A., Shmayun, S. S., & Guta, Z. A. (2020). Selenium in natural environment and food chains. A review. Ukrainian Journal of Ecology, 10(4), 148–158.

Szőllősi, L., Béres, E., & Szűcs, I. (2021). Effects of modern technology on broiler chicken performance and economic indicators – a Hungarian case study. Italian Journal of Animal Science, 20(1), 188–194.

Van Leeuwen, F. X. R., Den Tonkelaa, E. M., & Van Logten, M. J. (1983). Toxicity of sodium bromide in rats: Effects on endocrine system and reproduction. Food and Chemical Toxicology, 21(4), 383–389.

Vaskin, V. F., Korosteleva, O. N., Kuzmitskaya, A. A., Repnikova, V. I., & Khvostenko, T. M. (2021). Strategy of innovative development of animal husbandry in the Bryansk region. E3S Web of Conferences, 254, 08007.

Velický, J., Titlbach, M., Dusková, J., Vobecký, M., Strbák, V., & Raska, I. (1997). Potassium bromide and the thyroid gland of the rat: Morphology and immunohistochemistry, RIA and INAA analysis. Annals of Anatomy, 179(5), 421–431.

Velický, J., Titlbach, M., Lojda, Z., Dusková, J., Vobecký, M., Strbák, V. & Raska, I. (1998). Long-term action of potassium bromide on the rat thyroid gland. Acta Histochemica, 100(1), 11–23.

Verma, P. K., Sharma, A., Shankar, H., Sharma, A., & Rao, D. N. (2018). Role of trace elements, oxidative stress and immune system: A triad in premature ovarian failure. Biological Trace Element Research, 184(2), 325–333.

Vishchur, V. Y., Gutyj, B. V., Nischemenko, N. P., Kushnir, I. M., Salata, V. Z., Tarasenko, L. O., Khimych, M. S., Kushnir, V. I., Kalyn, B. M., Magrelo, N. V., Boiko, P. K., Kolotnytskyy, V. A., Velesyk, T., Pundyak, T. O., & Gubash, O. P. (2019). Effect of industry on the content of fatty acids in the tissues of the honey-bee head. Ukrainian Journal of Ecology, 9(3), 174–179.

Vlizlo, V. V. (2012). Laboratorni metody doslidzhen u biolohiji, tvarynnytstvi ta veterynarnij medytsyni [Laboratory research methods in biology, animal husbandry and veterinary medicine]. Spolom, Lviv (in Ukrainian).

Vobecký, M., & Babický, A. (1994). Effect of enhanced bromide intake on the concentration ratio I/Br in the rat thyroid gland. Biological Trace Element Research, 43, 509–516.

Vobecký, M., Babický, A., & Lener, J. (1996). Effect of increased bromide intake on iodine excretion in rats. Biological Trace Element Research, 55(3), 215–219.

Woodling, K. A., Chitranshi, P., Jacob, C. C., Loukotková, L., Von Tungeln, L. S., Olson, G. R., Patton, R. E., Francke, S., Mog, S. R., Felton, R. P., Beland, F. A., Zang, Y., & Gamboa da Costa, G. (2022). Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats. Food and Chemical Toxicology, 165, 113137.

World Health Organization (2018). Alternative drinking-water disinfectants: Bromine, iodine and silver. World Health Organization, Geneva.

Yatoo, M. I., Saxena, A., Deepa, P. M., Habeab, B. P., Devi, S., Jatav, R. S., & Dimri, U. (2013). Role of trace elements in animals: A review. Veterinary World, 6(12), 963–967.

Published
2023-03-04
How to Cite
Koreneva, Y. M., Orobchenko, O. L., Romanko, M. Y., Malova, N. G., Sachuk, R. M., Gutyj, B. V., & Radzykhovskyi, M. L. (2023). Influence of high-bromine poultry products on clinical-biochemical blood parameters of white rats . Regulatory Mechanisms in Biosystems, 14(1), 125-130. https://doi.org/10.15421/022319

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