Clinical-diagnostic criteria and peculiarities of treatment of urocystitis in cats

Keywords: urinary tract diseases; ultrasound examination;extracts of cranberries; pH of urine; Cystocure; blood and urine indexes.


The results of a study of cats with signs of urocystitis are presented. The general principles of diagnostics based on clinical, laboratory and additional research methods are established. Clinically acute urocystitis was manifested by disorders of urination – pollakiuria, dysuria, stranguria. Some of the animals showed an increase in body temperature, pain in the bladder and tightness of the walls of the abdominal cavity. According to the results of urine study, it was observed that 43.7% of the cats with urocystitis showed an increase in relative density of the urine, a change in urine pH towards higher alkaline levels, urine residue – erythrocytes, leukocytes and microorganisms were indicated. Impurities of salt and sand were found in 58.4% of the cats. In 31.4% of the cats, urocystitis was a complication of urolithiasis. Early diagnosis, especially differential diagnosis of acute and chronic, secondary urocystitis presents difficulties. Therefore, in cases of suspected inflammatory diseases of the urinary tract, a complex examination using ultrasound of the kidneys, bladder, prostate gland (in males) and the uterus (in females) is recommended.With therapeutic purpose, sick cats (two groups of 8 animals/group) were administered: anti-microbial agent (5% solution of Enrofloxacin), spasmolytic medicinal agent – Riabal®. Animals of the second group were additionally administered the drug Cystocure (Candioli Farmaceutici). According to the instructions, the plant basis of the powder Cystocure is presented by extracts of cranberries and orange peels. These substances provide the main properties of the drug – help in resisting the bacterial colonization of the lower urinary tract and change in urine pH to the acid side. The applied therapy positively influenced the clinical condition of the cats. Their general health was improved, painful sensations during the act of urination disappeared, the quantity and frequency of diuresis normalized. On the seventh day of treatment, according to the results of the study, the urine became transparent, no microorganisms were detected. In cats of the second group, which additionally used the drug Cystocure, the amount of salts and sand decreased significantly, the pH of the urine did not exceed the recommended value of 6.4, in contrast to animals of the first group.


Adamama-Moraitou, K. K., Paitaki, C. G., Rallis, T. S., & Tontis, D. (2001). Aspergillus species cystitis in a cat. Journal of Feline Medicine and Surgery, 3(1), 31–34.

Bailiff, N. L., Nelson, R. W., Feldman, E. C., Westropp, J. L., Ling, G. V., Jang, S. S., & Kass, P. H. (2006). Frequency and risk factors for urinary tract infection in cats with diabetes mellitus. Journal of Veterinary Internal Medicine, 20, 850–855.

Bailiff, N. L., Westropp, J. L., Nelson, R. W., Sykes, J. E., Owens, S. D., & Kass, P. H. (2008). Evaluation of urine specific gravity and urine sediment as risk factors for urinary tract infections in cats. Veterinary Clinical Pathology, 37(3), 317–322.

Bartges, J. W. (2012). Chronic kidney disease in dogs and cats. Veterinary Clinics: Small Animal Practice, 42(4), 669–692.

Brown, C. A., Jeong, K-S., Poppenga, R. H., Puschner, B., Miller, D. M., Ellis, A. E., Kang, K., Sum, S., Cistola, A. M., & Brown, S. A. (2007). Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. Journal of Veterinary Diagnostic Investigation, 19, 525–531.

Cottam, Y. H., Caley, P., Wamberg, S., & Hendriks, W. H. (2002). Feline reference values for urine composition. The Journal of Nutrition, 132(6), 1754–1756.

Di Martino, P., Agniel, R., David, K., Templer, C., Gaillard, J. L., Denys, P., & Botto, H. (2006). Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: A double-blind randomi zed placebo-controlled cross-over trial. World Journal of Urology, 24(1), 21–27.

Dorsch, R., Vopelius-Feldt, C., Wolf, G., Mueller, R. S., Straubinger, R. K., & Hartmann, K. (2016). Tierärztliche praxis kleintiere, 44, 227–236.

Dreikorn, K. (2005). Complementary and alternative medicine in urology. British Journal of Urology, 96(8), 1177–1184.

Ergin, İ., Şen, Y., Şenel, O. O., Özgermen, D. B., & Bumin, A. (2018). Radiological and ultrasonographical evaluation of lower urinary tract diseases in cats. Veterinary Journal of Ankara University, 65, 73–78.

Eydelnant, I. A., & Tufenkji, N. (2008). Cranberry derived proanthocyanidins reduce bacterial adhesion to selected biomaterials. Langmuir, 24(18), 10273–10281.

Farrow, C. S. (2003). Kidney, ureteral bladder, prostatic and urethral disease. In: Farrow, C. S. (Ed.). Veterinary diagnostic imaging: The dog and cat. Mosby Inc., Philadelphia.

Finke, M. D., & Litzenberger, B. A. (1992). Effect of intake on urine pH in cats. Journal of Small Animal Practice, 33(6), 261–265.

Grauer, G. F. (2005). Early detection of renal damage and disease in dogs and cats. Veterinary Clinics: Small Animal Practice, 35(3), 581–596.

Gupta, K., Chou, M. Y., Howell, A., Wobbe, C., Grady, R., & Stapleton, A. E. (2007). Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. The Journal of Urology, 177(6), 2357–2360.

Heinonen, M. (2007). Antioxidant activity and antimicrobial effect of berry phenolics – a Finnish perspective. Molecular Nutrition Food Research, 51(6), 684–691.

Hesse, A., Steffes, H.-J., & Graf, C. (1998). Pathogenic factors of urinary stone formation in animals. Journal of Animal Physiology and Animal Nutrition, 80, 108–119.

Hostutler, R. A., Chew, D. J., & DiBartola, S. P. (2005). Recent concepts in feline lower urinary tract disease. Veterinary Clinics: Small Animal Practice, 35(1), 147–170.

Howell, A. B. (2007). Bioactive compounds in cranberries and their role in pre vention of urinary tract infections. Molecular Nutrition Food Research, 51(6), 732–737.

Jepson, R. E., Elliott, J., Brodbelt, D., & Syme, H. M. (2007). Effect of control of systolic blood pressure on survival in cats with systemic hypertension. Jour nal of Veterinary Internal Medicine, 21(3), 402–409.

Jepson, R., & Craig, J. (2008). Cranberry for preventing urinary tract infections. Cochrane Database of Systematic Reviews, 23(1), CD001321.

Jessen, L. R., Sorensen, T. M., Bjornvad, C. R., Saxmose Nielsen, S., & Guardabassi, L. (2015). Effect of antibiotic treatment in canine and feline urinary tract infecti ons: A systematic review. The Veterinary Journal, 203(3), 270–277.

Jin, Y., & Lin, D. (2005). Fungal urinary tract infections in the dog and cat: A ret rospective study (2001–2004). Journal of the American Animal Hospital Association, 41(6), 373–381.

Kealy, J. K., Mcallister, H., & Graham, J. P. (2011). The abdomen. Diagnostic radiology and ultrasonography of the dog and cat. Saunders Elsevier, USA. Pp. 23–198.

Kienzle, E., Schuknecht, A., & Meyer, H. (1991). Influence of food consumption on the urine pH in cats. The Journal of Nutrition, 121, 87–88.

Kruger, J. M., & Osborne, C. A. (1990). The role of viruses in feline lower urinary tract disease. Journal of Veterinary Internal Medicine, 4(2), 71–78.

Kumar, V., Kumar, A., & Varshney, A. C. (2011). Ultrasonographic imaging for structural characterization of renal affections and diagnosis of associated chronic renal failure in 10 dogs. ISRN Veterinary Science, 2011, ID 901713.

Lavigne, J.-P., Bourg, G., Botto, H., & Sotto, A. (2007). Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature. Pathologie Biologie (Paris), 55(8–9), 460–464.

Liu, Y., Black, M. A., Caron, L., & Camesano, T. A. (2006). Role of cranberry juice on molecular-scale surface characteristics and adhesion behavior of E. coli. Biotechnology and Bioengineering, 93(2), 297–305.

Markwell, P. J., Buffington, C. T., & Smith, B. H. E. (1998). The effect of diet on lower urinary tract diseases in cats. The Journal of Nutrition, 128(12), 2753–2757.

O'Neill, D. G., Elliott, J., Church, D. B., McGreevy, P. D., Thomson, P. C., & Brodbelt, D. C. (2013). Chronic kidney disease in dogs in UK veterinary practices: Prevalence, risk factors, and survival. Journal of Veterinary Internal Medicine, 27, 814–821.

Park, H.-H., Lee, S., Son, H.-Y., Park, S.-B., Kim, M.-S., Choi, E.-J., Singh, T. S. K., Ha, J.-H., Lee, M.-G., Kim, J.-E., Hyun, M. C., Kwon, T. K., Kim, Y. H., & Kim, S.-H. (2008). Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Archives of Pharmacal Research, 31(10), 1303–1311.

Parys, M., Yuzbasiyan-Gurkan, V., & Kruger, J. M. (2018). Serum cytokine pro filing in cats with acute idiopathic cystitis. Journal of Veterinary Internal Medicine, 32(1), 274–279.

Platt, J. F., Ellis, J. H., Rubin, J. M., DiPietro, M. A., & Sedman, A. B. (1990). Intrarenal arterial Doppler sonography in patients with nonobstructive renal disease: Correlation of resistive index with biopsy findings. American Journal of Roentgenology, 154(6), 1223–1227.

Pouchelon, J. L., Atkins, C. E., Bussadori, C., Oyama, M. A., Vaden, S. L., Bona gura, J. D., Chetboul, V., Cowgill, L. D., Elliot, J., Francey, T., Grauer, G. F., Fuentes, L. V., Moise, S. N., Polzin, D. J., Van Dongen, A. M., & Van Israël, N. (2015). Cardiovascular-renal axis disorders in the domestic dog and cat: A vete rinary consensus statement. Journal of Small Animal Practice, 56(9), 537–552.

Semyonov, А., Shulzhenko, N., & Danylenko, V. (2015). Efektyvnist preparatu uro-vaksom za hostroho urotsystytu u kotiv [Efficacy of the medicine Uro-Vaksom for acute urocystitis in cats]. Science and Technology Bulletin of SRC for Biosafety and Environmental Control of AIC, 4(3), 46–51 (in Ukrainian).

Shulzhenko, N. N., & Ryabik, A. P. (2017). Efektyvnist kompleksnoho likuvan nia u sobak za hepatorenalnoho syndromu [Efficiency of complex treatment of hepatorenal syndrome in dogs]. Science and Technology Bulletin of SRC for Biosafety and Environmental Control of AIC, 5(1), 37–41 (in Ukrainian).

Weese, J. S., Blondeau, J. M., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Hillier, A., Lloyd, D. H., Papich, M. G., Rankin, S. C., Turnidge, J. D., & Sykes, J. E. (2011). Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: Antimicrobial guidelines working group of the international society for companion animal infectious diseases. Veterinary Medicine International, 2011, ID 263768.

Wynn, S. G., & Fougère, B. J. (2007). Veterinary herbal medicine. Elsevier, St. Louis, USA.

How to Cite
Shulzhenko, N. M., ChernenkoО. М., Holubyev, O. V., BordunovaО. G., & Suslova, N. I. (2019). Clinical-diagnostic criteria and peculiarities of treatment of urocystitis in cats . Regulatory Mechanisms in Biosystems, 10(1), 26-31.