γ-glutamyl tranferase in a model of carcinogenesis in rats
Abstract
For the first time activity of membrane bound and soluble forms of γ-glutamyl transferase in the rat erythrocytes under the model tumour in vivo and under correction of the pathological state by complexcompounds of rhenium (III) with organic ligands and cisplatin (rhenium-platinum system) was studied. The increased activity of the membrane bound enzyme and decrease of its cytosolic activity in the red blood cells during development of Guerin’s carcinoma T8 was found. Also the positive impact of the rheniumplatinum system on the enzymatic activity in the erythrocytes was shown, namely: the reduction of membrane bound and increase of cytosolic activity. As a result, the ratio between activity of the membrane bound enzyme and cytosolic one verged towards the correct level. The conclusion was made that the use of membrane bound and soluble γ-glutamyl transferase in the erythrocytes as a diagnostic enzyme of carcinogenesis is reasonable.References
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