Association of group erythrocyte antigens and B-cell non-Hodgkin lymphoma

U. V. Tymoshenko; S. O. Sivkovych; K. G. Garkava; R. P. Pavlyuk; G. A. Myronenko

doi:10.15421/021620

U. V. Tymoshenko State Institution “Institute of Haematology and Transfusiology of NAMS of Ukraine”
S. O. Sivkovych State Institution “Institute of Haematology and Transfusiology of NAMS of Ukraine”
K. G. Garkava Institute of Ecological Safety of National Aviation University
R. P. Pavlyuk State Institution “Institute of Haematology and Transfusiology of NAMS of Ukraine”
G. A. Myronenko State Institution “Institute of Haematology and Transfusiology of NAMS of Ukraine”

Keywords: antigen D, blood groups, hemoblastoses, association, risk factor

Abstract

We analyzed the frequency distribution of blood groups AB0, Rhesus and Kell in patients with B-cell non-Hodgkin lymphoma. An increase of D− patients (31.0%) among ill in comparison to healthy individuals (16.5%) was found. Based on published data, we exclude weakening or alteration of the D antigen for this pathology. We found an association of B-cell non-Hodgkin lymphoma and D− phenotype. It is established that the chances of developing the disease in D− individuals is 2 times higher than for D+ individuals. However, we did not find a significant association of frequency of minor antigens Rhesus (C, c, E, e, CW), K antigen Kell system, A and B antigens AB0 system and the development of B-cell non-Hodgkin lymphoma. We have analyzed the statistics of incidence of non-Hodgkin lymphoma inWestern Europeand Asian countries. We noticed a roughly twofold increase in the incidence of non-Hodgkin lymphoma inWestern Europecompared to Asian countries, where the proportion of D− individuals is almost zero. Parallel with the results of our study, it has been found that the chances of D– persons developing B-cell non-Hodgkin lymphoma are twice as high as for D+ individuals. InUkraine,BelarusandRussiathe incidence of non-Hodgkin lymphoma is almost at the level of Asian countries even though the percentage of D– individuals corresponds to Western European countries (15–16%). This can be explained by other genetic factors, or reduction in quality of care and diagnostics in post-Soviet countries compared toWestern Europe. Thus, D antigen may have a protective role in the morbidity of non-Hodgkin lymphoma.

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