The effect of carnitine, vitamins E and B12, methionine, selenium, and zinc as part of a complex preparation on the antioxidant status of rats under conditions of toxic liver injury
Abstract
The relevance of this study stems from the fact that toxic liver injury is accompanied by the development of oxidative stress, which leads to structural and functional damage to hepatocytes, as well as disruption of the activity of key antioxidant defense enzymes. The study aimed to investigate the effect of Devivit Carnitine on lipid peroxidation parameters and the state of the glutathione antioxidant defense system in rats under conditions of carbon tetrachloride intoxication. The experiment was conducted on three groups of animals: a control group, an experimental group with carbon tetrachloride - induced liver injury, and an experimental group that received Devivit Carnitine in addition to carbon tetrachloride intoxication. Devivit Carnitine is a multicomponent preparation containing carnitine hydrochloride, vitamins E and B 12 , methionine, selenium, and zinc. The levels of lipid hydroperoxides, TBA-active products, glutathione peroxidase activity, and reduced glutathione content in the blood of rats were assessed on days 2, 5, 10, and 14 of the experiment. Carbon tetrachloride intoxication caused a marked increase in lipid hydroperoxides and TBA-active products in the blood, along with inhibition of glutathione peroxidase activity and decreased glutathione content. Administration of Devivit Carnitine under these conditions significantly reduced lipid hydroperoxide and TBA-active product levels and normalized glutathione system parameters. By day 14, lipid hydroperoxide levels in animals of this group were close to physiological values, while glutathione peroxidase activity and reduced glutathione content reached control levels. The results confirm that Devivit Carnitine demonstrates pronounced antioxidant properties, manifested through inhibition of free radical oxidation processes and activation of both enzymatic and non-enzymatic components of antioxidant defense. The preparation may be a promising therapeutic agent in the complex treatment of toxic hepatoses, particularly those associated with oxid a tive stress, helping preserve the structural and functional integrity of the liver.References
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