Treatment of burns with polyethylene glycol-based preparations: Dynamics of regeneration at the biochemical and histological levels of organization in rats
Abstract
In Ukraine, more than 12 thousand children and a large number of adults suffer burn injuries yearly. Almost one in four cases is classified as severe or extremely severe. Currently, the system of medical care for burn survivors is in an extremely critical condition. Ukraine is among the five countries with the highest rate of deaths caused by burns in the world. Before the full-scale war, most burn injuries resulted from domestic incidents: careless handling of kitchen appliances, electrical appliances or pyrotechnic products. In adults, in 80% of casualties, the cause was fire, and among children (70%) – boiling water. After 2022, the situation has changed dramatically. In 2023 alone, more than 35% of the victims sustained burns during military attacks. Mine-explosive injuries are considered particularly severe and are often accompanied by extensive burns of various parts of the body. Such injuries require immediate surgery, professional assistance and a long-term rehabilitation process. In addition, due to regular shelling of critical infrastructure facilities and interruptions in electricity and gas supply, the number of household burns has increased dramatically. The most common causes are explosions of gas cylinders, ignition of generators, fires in homes, and boiling water burns. This article presents the findings of an experimental study of the effectiveness of treatment of burn injuries using anti-burn agents. In laboratory rats, thermal skin injuries with an area of up to 10% of the total body surface were induced, which corresponded to II – III degree burns. During the experiment, the therapeutic effect of the preparation under study, which was developed based on polyethylene glycol, was compared with the officially registered me d ical product – Pantestin ointment. Particular attention was paid to the analysis of pathophysiological and pathomorphological changes accompanying the course of burn injury. The most pronounced therapeutic effect was recorded with the use of the experimental ointment based on polyethylene glycol. On the fifth day of the experiment, the survival rate of animals in the group receiving this product was 100 %, while for the group treated with Pantestin, the rate was 60%, and among untreated control animals, the mortality rate reached 40%.References
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