Exploring biomarkers, adipokines, and cytokines in patients with colon cancer: A comparative study with healthy controls
Abstract
Cancer is the main reason people die in rich countries and the second most common reason people die in poor countries. Colon cancer (CRC) is the third most common type of cancer in the world. The aim of the study is to analyze and compare the profiles of adipokines and cytokine in colon cancer patients and healthy controls, and determine their potential role in the pathophysiology of colon cancer. This case-control study included 150 colon cancer patients (90 men, 60 women) and 50 healthy controls (25 men, 25 women), aged 55-65 years. The research was c onducted at Al-Haboubi Teaching Hospital from 1/1/2024 to 1/9/2024, with ethical approval. Blood samples were collected, clotting, and centrifuged to separate serum. The study found that colon cancer patients had higher BMI, smoking rates, and family history of cancer. They showed lower adiponectin levels and higher levels of le p tin, resistin, visfatin, and chemerin. Levels of c ytokines (TNF-α, IL-6, IL-10, IFN-γ, IL-1β) were significantly el e vated. Lipid profiles revealed increased total cholesterol, LDL, and triglycerides, but lower HDL. Adipokines d e creased with cancer stage, while TNF-α increased, with significant correlations among adipokines, cytokines, and lipids. The study links altered adipokines, cytokines, and lipid levels to colon cancer, with elevated TNF-α and reduced adiponectin indicating inflammation and metabolic dysregulation in disease progression.References
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