Evaluation of the levels of vimentin, neural cell adhesion molecule, C-X-C motif chemokine ligand 10, toll-like receptor 4, and some minerals in patients with multiple sclerosis
Abstract
Multiple sclerosis is a complex autoimmune disorder of the central nervous system and is believed to be caused by dysfun c tion of the immune system, characterized by inflammatory demyelination with axonal transection. Sixty blood samples were collected from patients (25 females and 35 males) suffering from multiple sclerosis (MS) who visited the MS consultant at Bag h dad Teaching Hospital, affiliated to the Medical City. Patients were collected from different age groups ranging from 20 – 40 years. Forty samples (15 females and 25 males) were collected from healthy individuals as a control group. Several biochem i cal parameters were tested, such as v imentin, neural cell adhesion molecule-NCAM, C-X-C motif chemokine ligand 10 ( CXCL10 ) , toll -like receptor 4 ( TLR4 ) , magnesium , zinc in the patients ’ blood serum. The results of the current study indicated a significant increase in v imentin, NCAM, CXCL10, TLR4 concentration in the blood serum of the G1 group compared to the control group. Also, the result showed a significant low in Mg, Zn concentration in the blood serum of the G1 group compared to the control group. The results also showed a highly significant positive correlation between vimentin concentration and NCAM, TLR4, CXCL10, Mg, Zn in the blood serum of the healthy group, which reache d correlation coefficients was 0.557, 0.848, 0.928, 0.633, 0.640, respectively. The results also showed that the area under curve value for the studied variables was excellent, as they can be considered important diagnostic variables for patients with multiple sclerosis.References
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