The mechanism of adaptation of the organism of patients with chronic heart failure combined with vitamin D deficiency and the morphofunctional state of peripheral blood erythrocytes

  • N. I. Baryla Ivano-Frankivsk National Medical University
  • I. P. Vakaliuk Ivano-Frankivsk National Medical University
  • S. L. Pоpеl’ Precarpathian National University named after V. Stefanik
Keywords: chronic heart failure; vitamin D; erythrocytes; physical activity; morpho-biochemical changes

Abstract

The problem of structural changes in peripheral blood erythrocytes in patients with chronic heart failure in combination with vitamin D deficiency during exercise stress remains insufficiently studied. Vitamin receptors are located on smooth myocytes, endothelial cells, cardiomyocytes and blood cells. It affects the state of the cell membrane, the contractile function of the myocardium, the regulation of blood pressure, cardiac remodeling and reduction of left ventricular hypertrophy. Therefore, it is important to assess the level of vitamin D in blood plasma in individuals with chronic heart failure and to identify the effect of its deficiency on the state of peripheral red blood cells when performing a 6-minute walk test. A total of 75 patients of the main group with chronic heart failure stage II A, I–II functional class with different levels of vitamin D deficiency were examined. The control group included 25 patients with chronic heart failure stage II A, functional class I–II without signs of vitamin D deficiency. The average age of patients was 57.5 ± 7.5 years. All patients were asked to undergo the 6 minutes walking test. The level of total vitamin D in plasma was determined by enzyme immunoassay. Morphological studies of erythrocytes were performed on the light-optical and electron-microscopic level. The obtained results showed that patients of the main group with chronic heart failure had a decrease in vitamin D by 2.2 times compared with the control group. Correlation analysis showed a directly proportional relationship between vitamin D deficiency and the number of red blood cells of a modified form and red blood cells with low osmotic resistance. Dosed exercise stress in patients with chronic heart failure against a background of vitamin D deficiency leads to an increase in the number of reversibly and irreversibly deformed erythrocytes and a decrease in their osmotic stability. This indicates a disorder in the structural integrity of their membrane and can have negative consequences for the somatic health of such patients.

References

Akіn, F., Ayca, B., & Kose, N. (2014). Serum vitamin D and c-reactive protein levels are independently associated with diastolic dysfunction. Journal of Investigative Medicine, 62(1), 43–48.

Chang, Y., & Bo, B. (2015). Effects of exhaustive exercise on the ATP-sensitive potassium channel of rat cardiac sinoatrial node. Journal of Science and Medicine in Sport, 19, 65–70.

Dalbeni, A., Scaturro, G., & Degan, M. (2014). Effects of six months of vitamin D supplementation in patients with heart failure: A randomized double-blind controlled trial. Nutrition, Metabolism, and Cardiovascular Diseases, 24(8), 861–868.

Demir, M., Gunay, T., & Ozmen, G. (2013). Relationship between vitamin D deficiency and non dipper hypertension. Clinical and Experimental Hypertension, 35(1), 45–49.

Ekwaru, J. P., Ohinmaa, A., & Veugelers, P. J. (2016). The effectiveness of a preventive health program and vitamin D status in improving health-related quality of life of older Canadians. Quality of Life Research, 25(3), 661–668.

Gorshkova, M. A., Petrova, M. B., & Miller, D. A. (2017). Modifikacija metoda opredelenija osmoticheskoj rezistentnosti eritrocitov [Modification of the method for determining the osmotic resistance of erythrocytes]. Tver Medical Journal, 1, 12–17 (in Russian).

Holick, M. F. (2017). Vitamin D (calciferol) metabolism. Reactome – a curated knowledge base of biological pathways. Physiological Reviews, 63, 266–281.

Imaizumi, T., Hirooka, Y., & Takeshita, A. (2012). Decreased skeletal muscle vasodilation in patients with congestive heart failure. Japanese Circulation Journal, 56(5), 500–503.

Katz, S. D. (2004). Mechanisms and treatment of anemia in chronic heart failure. Congestive Heart Failure, 10(5), 243–247.

Kenny, M. W., Meakin, M., & Stuart, J. (2016). Measurement of erythrocyte filterability using washed-erythrocyte and whole-blood methods. Clinical Hemorheology and Microcirculation, 2, 135–146.

Kleijn, L., Westenbrink, B. D., & van der Meer, P. (2013). Erythropoietin and heart failure: The end of a promise? European Journal of Heart Failure, 15, 479–481.

Klein, W. (2000). Guidelines abstracted from consensus recommendations for the management of chronic heart failure. Journal of the American Geriatrics Society, 48(11), 1521–1524.

Komoltri, C., Udombhornprabha, A., Boonhong, J., Tejapongvorachai, T., & Sermsri, S. (2011). Quality of life for Thai hip fracture patients: Assessments with medical outcomes study, a 36-item short form survey (MOS SF-36) and one-year health care resource utilization in a public hospital. Value in Health, 14(7), 314–317.

Lambert, M. I. (2016). General adaptations-exercise: Acute versus chronic and strength versus endurance training. Exercise and Human Reproduction. Springer, New York; Heidelberg Dordrecht, London.

Leslie, R., George, R., & Buckley, J. P. (2013). Efficacy of a 2-min versus a full 6-min practice walk before a 6-min walk test in heart failure patients. Heart, 99(2), 17–19.

Lim, G. B. (2016). Vitamin D supplementation in chronic heart failure. Nature Reviews Cardiology, 13(6), 312–312.

Limsuwan, A. (2010). Correlation between the 6-min walk test and exercise stress test. Acta Paediatrica, 99(7), 958–959.

Marín-García, J. (2010). Treatment of chronic heart failure. Heart Failure, 3, 379–392.

Meems, L. M., Cannon, M. V., & Mahmud, H. (2012). The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. The Journal of Steroid Biochemistry and Molecular Biology, 132, 282–289.

Mohammed, R., Haitham, G., & Mabrouk, A. S. O. (2015). Correlation between serum vitamin D level and cardiac function: Echo-cardiographic assessment. Egypt Heart Journal, 67(4), 299–305.

Motsinger, S. (2012). Vitamin D and health-related quality of life in older women. Maturitas, 35, 308–316.

Popel, S. L., Mytckan, B. M., Lapkovskyi, E. Y., Lisovskyi, B. P., Yatciv, Y. N., Zemskaya, N. O., Tyagur, R. S., Mytckan, T. S., Tkachivska, I. M., Kovalchuk, L. V., Leschak, O. N., Fаyichak, R. І., Melnik, I. V., & Markiv, G. D. (2017). Mechanism of changing adaptation potential and morpho-biochemical parameters of erythrocytes in students with different mode of day after physical load. Regulatory Mechanisms in Biosystems, 89(2), 66–70.

Popel’, S. L., Tsap, I. G., Yatciv, Y. N., Lapkovsky, E. Y., Synitsya, A. V., & Pyatnichuk, D. V. (2017). Osoblyvі aspekty gemodynamіky ta reakcіji eritrocytіv u krovі do standartnoho fіzychnoho navantazhennja rіznoji kvalіfіkacіji zhіnochyh volejbolіstіv [Special aspects of hemodynamic and reaction of erythrocytes in blood to standard physical load female volleyball players of different qualification]. Pedagogics, Psychology, Medical Biological Problems of Physical Training and Sports, 5, 251–259 (in Ukranian).

Rai, V., & Agrawal, D. K. (2017). Role of vitamin D in cardiovascular diseases. Endocrinology and Metabolism Clinics of North America, 46(4), 1039–1059.

Singh, S. J., Spruit, M. A., Troosters, T., & Holland, A. E. (2015). The 6-min walk test in patients with COPD: Walk this way! Thorax, 70(1), 86–88.

Sinha, R., van den Heuvel, W. J. A., & Arokiasamy, P. (2013). Validity and reliability of MOS short form health survey (SF-36) for use in India. Indian Journal of Community Medicine, 38(1), 22–25.

Stewart, M. (2007). The medical outcomes study 36-item short-form health survey (SF-36). Australian Journal of Physiotherapy, 53(3), 208–210.

Swedberg, К., Young, J. B., Anand, I. S., Cheng, S., Desai, A. S., & Diaz, R. (2013). Treatment of anemia with darbepoetin alfa in systolic heart failure. The New England Journal of Medicine, 368, 1210–1219.

Tavazzi, L. (2001). Physical training as a therapeutic measure in chronic heart failure: Time for recommendations. Heart, 86(1), 7–11.

Vinogradova, N. G. (2019). Gorodskoj centr lechenija hronicheskoj serdechnoj nedostatochnosti: Organizacija raboty i jeffektivnost' lechenija bol'nyh hronicheskoj serdechnoj nedostatochnost'ju [City center for the treatment of chronic heart failure: The organization of work and the effectiveness of treatment of patients with chronic heart failure]. Kardiologiia, 59(2), 31–39 (in Russian).

Wang, T. Q., & Wells, Q. S. (2015). Vitamin D deficiency and heart failure risk. Journal of American College of Cardiology: Heart Failure, 3(5), 357–359.

Warren, A. J. (2017). Decoding erythropoiesis. Blood, 129(5), 544–545.

Witham, M. D. (2011). Vitamin D in chronic heart failure. Current Heart Failure Reports, 8(2), 123–130.

Zhang, W., & Wang, P. (2018). Quality of life among men who have sex with men in China measured using the 36-item short-form health survey. Medicine, 97(27), 11310–11315.

Zittermann, A., Prokop, S., Gummert, J. F., & Börgermann, J. (2013). Safety issues of vitamin D supplementation. Anticancer Agents in Medicinal Chemistry, 13(1), 4–10.

Published
2019-07-21
How to Cite
Baryla, N. I., Vakaliuk, I. P., & Pоpеl’S. L. (2019). The mechanism of adaptation of the organism of patients with chronic heart failure combined with vitamin D deficiency and the morphofunctional state of peripheral blood erythrocytes . Regulatory Mechanisms in Biosystems, 10(3), 352-357. https://doi.org/10.15421/021954