@article{Zhaleyko_Bilko_Dyagil_Bilko_2014, title={Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation}, volume={5}, url={https://medicine.dp.ua/index.php/med/article/view/226}, DOI={10.15421/021420}, abstractNote={<p class="00Annotation"><span lang="UK">The efficiency of </span><span lang="EN-US">using </span><span lang="UK">the culture</span><span lang="EN-US"> techniques </span><span lang="UK">of research for monitoring </span><span lang="EN-US">the </span><span lang="UK">patient</span><span lang="EN-US">’s</span><span lang="UK"> response to </span><span lang="EN-US">the treatment by </span><span lang="UK">tyrosine kinase inhibitors of the first and second generation </span><span lang="EN-US">i</span><span lang="UK">s shown. Thus, the functional activity of bone marrow cells </span><span lang="EN-US">in</span><span lang="UK"> patients </span><span lang="EN-US">having </span><span lang="UK">the optimal treatment response to inhibitors of tyrosine kinases was significantly lower compared </span><span lang="EN-US">with </span><span lang="UK">patients with </span><span lang="EN-US">the </span><span lang="UK">acquired resistance to the drug, and patients who had CML diagnosed for first time. Furthermore, for patients with </span><span lang="EN-US">the</span><span lang="UK"> optimal response to the nilotinib therapy, numbers of colonies in semi</span><span lang="EN-US">-</span><span lang="UK">solid agar <em>in vitro</em> was l</span><span lang="EN-US">ower</span><span lang="UK">, </span><span lang="EN-US">than in </span><span lang="UK">patients </span><span lang="EN-US">with </span><span lang="UK">the optimal response to imatinib. When </span><span lang="EN-US">the </span><span lang="UK">leukaemic cell clone become</span><span lang="EN-US">s</span><span lang="UK"> resistant to tyrosine kinase inhibitors, </span><span lang="EN-US">the</span><span lang="UK"> prevalence of early cells of granulocyte-macrophage hematopoietic stem cells </span><span lang="EN-US">i</span><span lang="UK">s observed in CFU culture </span><span lang="EN-US">which can be </span><span lang="UK">an important prognostic factor for </span><span lang="EN-US">choosing the </span><span lang="UK">appropriate treatment strategy.</span></p&gt;}, number={2}, journal={Regulatory Mechanisms in Biosystems}, author={Zhaleyko, I. O. and Bilko, D. I. and Dyagil, I. S. and Bilko, N. M.}, year={2014}, month={Jul.}, pages={104-109} }