Impact of aqueous extract of Viscum album on different organisms
Keywords:
mistletoe; aqueous extract; host trees; onion; fruit flyes; antimicrobial activity; fungi species
Abstract
The phytochemical and pharmacological potential of Viscum album extracts are widely used for the treatment of various diseases in many countries. The effect of aqueous extract from different mistletoe host trees (Abies alba, Acer saccharinum, Malus domestica, Pinus sylvestris) on model objects (Allium cepa and Drosophila milanogaster), bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus), and fungi (Aspergillus niger, Heterobasidion annosum, Inonotus obliquus) was evaluated. The influence of mistletoe extracts on A. cepa, D. melanogaster and basidiomycetes species H. annosum and I. obliquus was demonstrated for the first time. The study findings revealed that the impact of mistletoe aqueous extract exhibits considerable variation, influenced by multiple factors. These factors include the specific tree from which mistletoe is obtained, the concentration used, and the organism targeted. Mistletoe extracts caused the appearance of cells with pathologies in the meristematic tissues of A. cepa at different stages of the plant cell cycle. A clear cytostatic effect on A. cepa and D. melanogaster was shown, with the highest effect of mistletoe extract obtained from A. saccharinum. The main action of the solution on cells is probably manifested in the inhibition of cell division according to the results of the cytotoxicity assessment of aqueous extracts of mistletoe. Antibacterial activity of concentated mistletoe extract obtained from A. saccharinum was found only against S. aureus with zone of growth inhibition 11.0 ± 0.1 mm. In the assay on agar plates the tested extracts stimulated the mycelial growth of A. niger 1.85 times higher compared to the control, but inhibited the growth of H. annosum, I. obliquus at 65.5% and 62.2%, respectively. However, the biomass production of H. annosum was strongly dependent on the host mistletoe tree of the aqueous extract, and both the inhibition of mycelial synthesis of the wood-destroying fungus and its stimulating effect on mycelial accumulation were found. A negative effect (1.46 times decrease in biomass ) of H. annosum was found in the case of application of mistletoe extract obtained from A. saccharinum. The highest stimulation effect on fungus (1.53 times increase in biomass) was established by using mistletoe extract prepared from A. alba. In this study the main effects on living organisms used were indirectly caused by the host trees of mistletoe extracts. The overall negative impact was associated with the host tree Acer saccharinum.References
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Akalazu, J. N., Ohazurike, N. C., & Onuoha, C. I. (2016). Antifungal activity of Viscum album (African mistletoe) leaf extract on Dioscorea rotundata (Poir) (White Yam) tuber rot disease. International Journal of Advances in Science, Engineering and Technology, 4(2), 189–191.
Alfredsen, G., Solheim, H., & Slimestad, R. (2008). Antifungal effect of bark extracts from some European tree species. European Journal of Forest Research, 127, 387–393.
Asiegbu, F. O., Adomas, A., & Stenlid, J. (2008). Conifer root and butt rot caused by Heterobasidion annosum (Fr.) Bref. s.l. Molecular Plant Pathology, 6(4), 395–409.
Becker, H. (2000). European mistletoe: Taxonomy, host trees, parts used, physiology. In: Büssing, A. (Ed.). Mistletoe: The genus Viscum. Hardwood Academic Publishers, Amsterdam. Pp. 31–44.
Bisko, N., Lomberg, M., Mykchaylova, O., & Mytropolska, N. (2020). IBK mushroom culture collection. Version 1.2. M. G. Kholodny Institute of Botany, Kyiv.
Bosio, S., & Laughinghouse, I. (2012). Bioindicator of genotoxicity: The Allium cepa test. In: Srivastava, J. K. (Ed.). Environmental contamination. IntechOpen.
Camarero, J. J., de Andrés, E. G., Sangüesa-Barreda, G., Rita, A., & Colangelo, M. (2019). Long- and short-term impacts of a defoliating moth plus mistletoe on tree growth, wood anatomy and water-use efficiency. Dendrochronologia, 56, 125598.
Deliorman, D., Ergun, F., Sener, B., & Palittapongarnpim, P. (2001). Evaluation of antimycobacterial activity of Viscum album subspecies. Pharmaceutical Biology, 39(5), 381–383.
Erturk, O. (2010). Antibacterial and antifungal effects of alcoholic extracts of 41 medicinal plants growing in Turkey. Czech Journal of Food Sciences, 28, 53–60.
Erturk, O., Katı, H., Yaylı, N., & Demirbağ, Z. (2003). Antimicrobial activity of Viscum album L. subsp. abietis (Wiesb). Turkish Journal of Biology, 27, 255–258.
González-Sarrías, A., Li, L., & Seeram, N. P. (2011). Effects of maple (Acer) plant part extracts on proliferation, apoptosis and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells. Phytotherapy Research, 26(7), 995–1002.
González-Sarrías, A., Li, L., & Seeram, N. P. (2012). Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. Journal of Functional Foods, 4(1), 185–196.
Halenar, M., Tvrda, E., Baldovska, S., Ondruška, L., Massanyi, P., & Kolesarova, A. (2017). In vitro effects of Viscum album on the functionality of rabbit spermatozoa. Engineering and Technology International Journal of Animal and Veterinary Sciences, 11(2), 108–112.
Huebner, J., Micke, O., Muecke, R., Buentzel, J., Prott, F. J., Kleeberg, U., Senf, B., & Muenstedt, K. (2014). User rate of complementary and alternative medicine (CAM) of patients visiting a counseling facility for CAM of a German Comprehensive Cancer Center. Anticancer Research, 34, 943–948.
Hussain, M. A., Khan, M. Q., Hussain, N., & Habib, T. (2011). Antibacterial and antifungal potential of leaves and twigs of Viscum album L. Journal of Medicinal Plants Research, 5, 5545–5549.
Jäger, T., Holandino, C., Melo, M. N. O., Peñaloza, E. M. C., Oliveira, A. P., Garrett, R., Glauser, G., Grazi, M., Ramm, H., Urech, K., & Baumgartner, S. (2021). Metabolomics by UHPLC-Q-TOF reveals host tree-dependent phytochemical variation in Viscum album L. Plants, 10(8), 1726.
JideFaleye, F., & Olatunya, A. M. (2016). Assessment of the antioxidant and antibacterial activities of Petiveria alliacea and Viscum album (mistletoe). International Journal of Advanced Research, 4, 1915–1919.
Keskin, D., & Ceyhan-Guvensen, N. (2018). Determination of bioactive components and antimicrobial activity of methanolic extracts of mistletoe leaves (Viscum album L. subsp. album L.). Fresenius Environmental Bulletin, 27(12), 7991–7996.
Kienle, G. S., & Keine, H. (2010). Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: A systematic review of controlled clinical studies. Integrative Cancer Therapies, 9(2), 142–157.
Kleszken, E., Purcarea, C., Pallag, A., Ranga, F., Memete, A. R., Miere (Groza), F., &Vicas, S. I. (2022). Phytochemical profile and antioxidant capacity of Viscum album L. subsp. album and effects on its host trees. Plants, 11(22), 3021.
Ladokun, O., Ojezele, M., & Arojojoye, O. (2015). Comparative study on the effects of aqueous extracts of Viscum album (Mistletoe) from three host plants on hematological parameters in albino rats. African Health Sciences, 15(2), 38.
Majeed, M., Pirzadah, T. B., Mir, M. A., Hakeem, K. R., Alharby, H. F., Alsamadany, H., Bamagoos, A. A., & Rehman, R. U. (2021). Comparative study on phytochemical profile and antioxidant activity of an epiphyte, Viscum album L. (white berry mistletoe), derived from different host trees. Plants, 10(6), 1191.
Marvibaigi, M., Supriyanto, E., Amin, N., Adibah, F., Majid, A., & Jaganathan, S. K. (2014). Preclinical and clinical effects of mistletoe against breast cancer. BioMed Research International, 11, 785479.
Matthes, H., Thronicke, A., Hofheinz, R.-D., Baars, E., Martin, D., Huber, R., Breitkreuz, T., Bar-Sela, G., Galun, D., & Schad, F. (2020). Statement to an insufficient systematic review on Viscum album L. therapy. Evidence-Based Complementary and Alternative Medicine, 18, 7091039.
Nicoletti, M. (2023). The anti-inflammatory activity of Viscum album. Plants, 12(7), 1460.
Oguntoye, S. O., Olatunji, G. A., Kolawole, O. M., & Enonbun, K. I. (2008). Phytochemical screening and antibacterial activity of Viscum album (Mistletoe) extracts. Plant Science Research, 1, 44–46.
Oubaid, E. N., Chabuck, Z. A. G., Al-Saigh, R. J., Hindi, N. K. K., & Kadhum, S. A. (2022). Pathogenic and antimicrobial properties of aquatic extracts of Viscus album and Apium graveolens. Asian Journal of Plant Sciences, 21, 629–636.
Park, Y. J., Mok, S. K., Kim, J. Y., Yun, S. S., & Park, S. C. (2021). Retroperitoneal Viscum album extract instillation inpatients with a large amount of drainage after kidney transplantation. Annals of Surgical Treatment and Research, 101(6), 368.
Pietrzak, W., & Nowak, R. (2021). Impact of harvest conditions and host tree species on chemical composition and antioxidant activity of extracts from Viscum album L. Molecules, 26(12), 3741.
Pietrzak, W., Nowak, R., Gawlik-Dziki, U., Lemieszek, M. K., & Rzeski, W. (2017). LC-ESI-MS/MS identification of biologically active phenolic compounds in mistletoe berry extracts from different host trees. Molecules, 22(4), 624.
Pilichowski, S., Filip, R., Kościelska, A., Żaroffe, G., Żyźniewska, A., & Iszkuło, G. (2018). Influence of Viscum album ssp. austriacum (Wiesb.) Vollm. on tree radial growth of Pinus sylvestris L. Sylwan, 162, 452–459 (in Polish).
Riaz, B., Zahoor, M. K., Zahoor, M. A., Majeed, H. N., Javed, I., Ahmad, A., Jabeen, F., Zulhussnain, M., & Sultana, K. (2018). Toxicity, phytochemical composition, and enzyme inhibitory activities of some indigenous weed plant extracts in fruit fly, Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine, 3, 2325659.
Sadananda, T. S., Govindappa, M., & Ramachandra, Y. L. (2014). In vitro antioxidant activity of lectin from different endophytic fungi of Viscum album L. British Journal of Pharmaceutical Research, 4(5), 626–643.
Segneanu, A.-E., Marin, C. N., Herea, D. D., Stanusoiu, I., Muntean, C., & Grozescu, I. (2022). Romanian Viscum album L. – untargeted low-molecular metabolomic approach to engineered viscum AuNPs carrier assembly. Plants, 11(14), 1820.
Shah, S. S., Rehman, Y. U., Iqbal, A., Rahman, Z. U., Zhou, B., Peng, M., & Li, Z. (2017). Phytochemical screening and antimicrobial activities of stem, leaves and fruit extracts of Viscum album L. Journal of Pure and Applied Microbiology, 11, 1337–1349.
Singh, B. N., Saha, C., Galun, D., Upreti, D. K., Bayry, J., & Kaveri, S. V. (2016). European Viscum album: A potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence. RSC Advances, 6(36), 23837–23857.
Sklyar, T., Kurahinaa. N., Lavrentieva, K., Burlaka, V., Lykholat, T., & Lykholat, O. (2021). Autonomic (mobile) genetic elements of bacteria and their hierarchy. Cytology and Genetics, 55(3), 256–269.
Stefanucci, A., Zengin, G., Llorent-Martinez, E. J., Pia Dimmito, M., Della Valle, A., Pieretti, S., Ak, G., Sinan, K. I., & Mollica, A. (2020). Viscum album L. homogenizer-assisted and ultrasound-assisted extracts as potential sources of bioactive compounds. Journal of Food Biochemistry, 44, e13377.
Suveren, E., Baxter, G. F., Iskit, A. B., & Turke, A. U. (2017). Cardioprotective effects of Viscum album L. subsp. album (European mistletoe) leaf extracts in myocardial ischemia and reperfusion. Journal of Ethnopharmacology, 209, 203–209.
Szurpnicka, A., Kowalczuk, A., & Szterk, A. (2020). Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action. Archives of Pharmacal Research, 43(6), 593–629.
Szurpnicka, A., Wronska, A. K., Bus, K., Kozinska, A., Jabłczynska, R., Szterk, A., & Lubelska, K. (2022). Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera). Journal of Ethnopharmacology, 298, 115604.
Teixeira, R. O., Camparoto, M. L., Mantovani, M. S., & Vicentini, V. E. P. (2003). Assesment of two medicinal plants Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays. Genetics and Molecular Biology, 26(4), 551–555.
Thomas, P. A., Dering, M., Giertych, M. J., Iszkuło, G., Tomaszewski, D., & Briggs, J. (2022). Biological flora of Britain and Ireland. Viscum album. Journal of Ecology, 111, 701–739.
Thronicke, A., Schad, F., Debus, M., Grabowski, J., & Soldner, G. (2022). Viscum album L. therapy in oncology: An update on current evidence. Complementary Medicine Research, 29, 362–368.
Valle, A. C. V., Brunel, H. D. S. S., Araújo, A. D. R. B., & De Carvalho, A. C. (2023). In vitro cytotoxic activity of different Viscum album potencies in glioma cells. International Journal of Health and Medical Research, 2(1), 4–6.
Walas, Ł., Kędziora, W., Ksepko, M., Rabska, M., Tomaszewski, D., Thomas, P. A., Wójci, R., & Iszkuło, G. (2022). The future of Viscum album L. in Europe will be shaped by temperature and host availability. Scientific Reports, 12, 17072.
Yousefvand, S., Fattahi, F., Hosseini, S. M., Urech, K., & Schaller, G. (2022). Viscotoxin and lectin content in foliage and fruit of Viscum album L. on the main host trees of Hyrcanian forests. Scientific Reports, 12, 10383.
Zhang, R.-Z., Zhao, J.-T., & Wang, W.-Q. (2016). Phenolic compounds in chilean mistletoe (quintral, Tristerix tetrandus) analyzed by UHPLC-Q/Orbitrap/MS/ MS and its antioxidant properties. Molecules, 21(3), 245.
Akalazu, J. N., Ohazurike, N. C., & Onuoha, C. I. (2016). Antifungal activity of Viscum album (African mistletoe) leaf extract on Dioscorea rotundata (Poir) (White Yam) tuber rot disease. International Journal of Advances in Science, Engineering and Technology, 4(2), 189–191.
Alfredsen, G., Solheim, H., & Slimestad, R. (2008). Antifungal effect of bark extracts from some European tree species. European Journal of Forest Research, 127, 387–393.
Asiegbu, F. O., Adomas, A., & Stenlid, J. (2008). Conifer root and butt rot caused by Heterobasidion annosum (Fr.) Bref. s.l. Molecular Plant Pathology, 6(4), 395–409.
Becker, H. (2000). European mistletoe: Taxonomy, host trees, parts used, physiology. In: Büssing, A. (Ed.). Mistletoe: The genus Viscum. Hardwood Academic Publishers, Amsterdam. Pp. 31–44.
Bisko, N., Lomberg, M., Mykchaylova, O., & Mytropolska, N. (2020). IBK mushroom culture collection. Version 1.2. M. G. Kholodny Institute of Botany, Kyiv.
Bosio, S., & Laughinghouse, I. (2012). Bioindicator of genotoxicity: The Allium cepa test. In: Srivastava, J. K. (Ed.). Environmental contamination. IntechOpen.
Camarero, J. J., de Andrés, E. G., Sangüesa-Barreda, G., Rita, A., & Colangelo, M. (2019). Long- and short-term impacts of a defoliating moth plus mistletoe on tree growth, wood anatomy and water-use efficiency. Dendrochronologia, 56, 125598.
Deliorman, D., Ergun, F., Sener, B., & Palittapongarnpim, P. (2001). Evaluation of antimycobacterial activity of Viscum album subspecies. Pharmaceutical Biology, 39(5), 381–383.
Erturk, O. (2010). Antibacterial and antifungal effects of alcoholic extracts of 41 medicinal plants growing in Turkey. Czech Journal of Food Sciences, 28, 53–60.
Erturk, O., Katı, H., Yaylı, N., & Demirbağ, Z. (2003). Antimicrobial activity of Viscum album L. subsp. abietis (Wiesb). Turkish Journal of Biology, 27, 255–258.
González-Sarrías, A., Li, L., & Seeram, N. P. (2011). Effects of maple (Acer) plant part extracts on proliferation, apoptosis and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells. Phytotherapy Research, 26(7), 995–1002.
González-Sarrías, A., Li, L., & Seeram, N. P. (2012). Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. Journal of Functional Foods, 4(1), 185–196.
Halenar, M., Tvrda, E., Baldovska, S., Ondruška, L., Massanyi, P., & Kolesarova, A. (2017). In vitro effects of Viscum album on the functionality of rabbit spermatozoa. Engineering and Technology International Journal of Animal and Veterinary Sciences, 11(2), 108–112.
Huebner, J., Micke, O., Muecke, R., Buentzel, J., Prott, F. J., Kleeberg, U., Senf, B., & Muenstedt, K. (2014). User rate of complementary and alternative medicine (CAM) of patients visiting a counseling facility for CAM of a German Comprehensive Cancer Center. Anticancer Research, 34, 943–948.
Hussain, M. A., Khan, M. Q., Hussain, N., & Habib, T. (2011). Antibacterial and antifungal potential of leaves and twigs of Viscum album L. Journal of Medicinal Plants Research, 5, 5545–5549.
Jäger, T., Holandino, C., Melo, M. N. O., Peñaloza, E. M. C., Oliveira, A. P., Garrett, R., Glauser, G., Grazi, M., Ramm, H., Urech, K., & Baumgartner, S. (2021). Metabolomics by UHPLC-Q-TOF reveals host tree-dependent phytochemical variation in Viscum album L. Plants, 10(8), 1726.
JideFaleye, F., & Olatunya, A. M. (2016). Assessment of the antioxidant and antibacterial activities of Petiveria alliacea and Viscum album (mistletoe). International Journal of Advanced Research, 4, 1915–1919.
Keskin, D., & Ceyhan-Guvensen, N. (2018). Determination of bioactive components and antimicrobial activity of methanolic extracts of mistletoe leaves (Viscum album L. subsp. album L.). Fresenius Environmental Bulletin, 27(12), 7991–7996.
Kienle, G. S., & Keine, H. (2010). Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: A systematic review of controlled clinical studies. Integrative Cancer Therapies, 9(2), 142–157.
Kleszken, E., Purcarea, C., Pallag, A., Ranga, F., Memete, A. R., Miere (Groza), F., &Vicas, S. I. (2022). Phytochemical profile and antioxidant capacity of Viscum album L. subsp. album and effects on its host trees. Plants, 11(22), 3021.
Ladokun, O., Ojezele, M., & Arojojoye, O. (2015). Comparative study on the effects of aqueous extracts of Viscum album (Mistletoe) from three host plants on hematological parameters in albino rats. African Health Sciences, 15(2), 38.
Majeed, M., Pirzadah, T. B., Mir, M. A., Hakeem, K. R., Alharby, H. F., Alsamadany, H., Bamagoos, A. A., & Rehman, R. U. (2021). Comparative study on phytochemical profile and antioxidant activity of an epiphyte, Viscum album L. (white berry mistletoe), derived from different host trees. Plants, 10(6), 1191.
Marvibaigi, M., Supriyanto, E., Amin, N., Adibah, F., Majid, A., & Jaganathan, S. K. (2014). Preclinical and clinical effects of mistletoe against breast cancer. BioMed Research International, 11, 785479.
Matthes, H., Thronicke, A., Hofheinz, R.-D., Baars, E., Martin, D., Huber, R., Breitkreuz, T., Bar-Sela, G., Galun, D., & Schad, F. (2020). Statement to an insufficient systematic review on Viscum album L. therapy. Evidence-Based Complementary and Alternative Medicine, 18, 7091039.
Nicoletti, M. (2023). The anti-inflammatory activity of Viscum album. Plants, 12(7), 1460.
Oguntoye, S. O., Olatunji, G. A., Kolawole, O. M., & Enonbun, K. I. (2008). Phytochemical screening and antibacterial activity of Viscum album (Mistletoe) extracts. Plant Science Research, 1, 44–46.
Oubaid, E. N., Chabuck, Z. A. G., Al-Saigh, R. J., Hindi, N. K. K., & Kadhum, S. A. (2022). Pathogenic and antimicrobial properties of aquatic extracts of Viscus album and Apium graveolens. Asian Journal of Plant Sciences, 21, 629–636.
Park, Y. J., Mok, S. K., Kim, J. Y., Yun, S. S., & Park, S. C. (2021). Retroperitoneal Viscum album extract instillation inpatients with a large amount of drainage after kidney transplantation. Annals of Surgical Treatment and Research, 101(6), 368.
Pietrzak, W., & Nowak, R. (2021). Impact of harvest conditions and host tree species on chemical composition and antioxidant activity of extracts from Viscum album L. Molecules, 26(12), 3741.
Pietrzak, W., Nowak, R., Gawlik-Dziki, U., Lemieszek, M. K., & Rzeski, W. (2017). LC-ESI-MS/MS identification of biologically active phenolic compounds in mistletoe berry extracts from different host trees. Molecules, 22(4), 624.
Pilichowski, S., Filip, R., Kościelska, A., Żaroffe, G., Żyźniewska, A., & Iszkuło, G. (2018). Influence of Viscum album ssp. austriacum (Wiesb.) Vollm. on tree radial growth of Pinus sylvestris L. Sylwan, 162, 452–459 (in Polish).
Riaz, B., Zahoor, M. K., Zahoor, M. A., Majeed, H. N., Javed, I., Ahmad, A., Jabeen, F., Zulhussnain, M., & Sultana, K. (2018). Toxicity, phytochemical composition, and enzyme inhibitory activities of some indigenous weed plant extracts in fruit fly, Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine, 3, 2325659.
Sadananda, T. S., Govindappa, M., & Ramachandra, Y. L. (2014). In vitro antioxidant activity of lectin from different endophytic fungi of Viscum album L. British Journal of Pharmaceutical Research, 4(5), 626–643.
Segneanu, A.-E., Marin, C. N., Herea, D. D., Stanusoiu, I., Muntean, C., & Grozescu, I. (2022). Romanian Viscum album L. – untargeted low-molecular metabolomic approach to engineered viscum AuNPs carrier assembly. Plants, 11(14), 1820.
Shah, S. S., Rehman, Y. U., Iqbal, A., Rahman, Z. U., Zhou, B., Peng, M., & Li, Z. (2017). Phytochemical screening and antimicrobial activities of stem, leaves and fruit extracts of Viscum album L. Journal of Pure and Applied Microbiology, 11, 1337–1349.
Singh, B. N., Saha, C., Galun, D., Upreti, D. K., Bayry, J., & Kaveri, S. V. (2016). European Viscum album: A potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence. RSC Advances, 6(36), 23837–23857.
Sklyar, T., Kurahinaa. N., Lavrentieva, K., Burlaka, V., Lykholat, T., & Lykholat, O. (2021). Autonomic (mobile) genetic elements of bacteria and their hierarchy. Cytology and Genetics, 55(3), 256–269.
Stefanucci, A., Zengin, G., Llorent-Martinez, E. J., Pia Dimmito, M., Della Valle, A., Pieretti, S., Ak, G., Sinan, K. I., & Mollica, A. (2020). Viscum album L. homogenizer-assisted and ultrasound-assisted extracts as potential sources of bioactive compounds. Journal of Food Biochemistry, 44, e13377.
Suveren, E., Baxter, G. F., Iskit, A. B., & Turke, A. U. (2017). Cardioprotective effects of Viscum album L. subsp. album (European mistletoe) leaf extracts in myocardial ischemia and reperfusion. Journal of Ethnopharmacology, 209, 203–209.
Szurpnicka, A., Kowalczuk, A., & Szterk, A. (2020). Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action. Archives of Pharmacal Research, 43(6), 593–629.
Szurpnicka, A., Wronska, A. K., Bus, K., Kozinska, A., Jabłczynska, R., Szterk, A., & Lubelska, K. (2022). Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera). Journal of Ethnopharmacology, 298, 115604.
Teixeira, R. O., Camparoto, M. L., Mantovani, M. S., & Vicentini, V. E. P. (2003). Assesment of two medicinal plants Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays. Genetics and Molecular Biology, 26(4), 551–555.
Thomas, P. A., Dering, M., Giertych, M. J., Iszkuło, G., Tomaszewski, D., & Briggs, J. (2022). Biological flora of Britain and Ireland. Viscum album. Journal of Ecology, 111, 701–739.
Thronicke, A., Schad, F., Debus, M., Grabowski, J., & Soldner, G. (2022). Viscum album L. therapy in oncology: An update on current evidence. Complementary Medicine Research, 29, 362–368.
Valle, A. C. V., Brunel, H. D. S. S., Araújo, A. D. R. B., & De Carvalho, A. C. (2023). In vitro cytotoxic activity of different Viscum album potencies in glioma cells. International Journal of Health and Medical Research, 2(1), 4–6.
Walas, Ł., Kędziora, W., Ksepko, M., Rabska, M., Tomaszewski, D., Thomas, P. A., Wójci, R., & Iszkuło, G. (2022). The future of Viscum album L. in Europe will be shaped by temperature and host availability. Scientific Reports, 12, 17072.
Yousefvand, S., Fattahi, F., Hosseini, S. M., Urech, K., & Schaller, G. (2022). Viscotoxin and lectin content in foliage and fruit of Viscum album L. on the main host trees of Hyrcanian forests. Scientific Reports, 12, 10383.
Zhang, R.-Z., Zhao, J.-T., & Wang, W.-Q. (2016). Phenolic compounds in chilean mistletoe (quintral, Tristerix tetrandus) analyzed by UHPLC-Q/Orbitrap/MS/ MS and its antioxidant properties. Molecules, 21(3), 245.
Published
2023-08-23
How to Cite
Bilonozhko, Y., Shut, T., Krupodorova, T., Pirko, N., Holubchak, O., Pryvalikhin, S., Lykholat, O., & Pirko, Y. (2023). Impact of aqueous extract of Viscum album on different organisms . Regulatory Mechanisms in Biosystems, 14(3), 432-438. https://doi.org/10.15421/10.15421/022363
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