Biological effects of iodine, selenium, sulfur citrates in broiler chickens
AbstractThis study aimed at the assessment of the I, Se, S citrate effect on the organism of broiler chickens. Feeding of chickens of all groups was carried out by using standard balanced feeds – starter, grower, and finish with the use of group feeders placed at the appropriate height from the floor depending on the poultry height. For the chickens of experimental groups, I, Se, S citrate was added to drinking water daily during the 48th day. To the drinking water of chickens of experimental groups different amounts of the citrate solution were added I (200 mg/L), Se (50 mg/L), S (300 mg/L), prepared by the nanotechnology method. Chickens of the II group received the lowest dose of I, Se, S at the rate of 5 μg I/L, 1.25 μg Se/L, 7.5 μg S/L of drinking water, and for poultry of other experimental groups, it was increased by 2 (III), 4 (IV), 6 (V) and 8 (VI) times compared to II group. Coccidiostat "Kokcisan 12%" (KRKA, Slovenia) was added to the starter and grower feed at the stages of its manufacture in quantities of 0.5 kg/t of feed. Coccidiostat was not added to the final feed. During the 48-day technological period, the clinical condition of the poultry was monitored daily by forage and motor activity, safety, and every 7 days – for growth intensity with the individual determination of body weight on a laboratory scale. The investigation of the blood was carried out from the 35th or 48th day during the growing, period and also investigation of the internal organs – liver, heart, spleen, stomach, thymus, and bursa of Fabricius. The increase of cholesterol, triacylglycerols, and albumin in the blood of II, III, and VI chicken groups was established on the 35th day of the experiment, and the reduction of creatinine in III and VI groups. By that time, the effect of highest dose of I, Se, S caused a decrease in the T3 concentration in the blood of chickens in the VI group compared to the I and II groups. In particular, in the blood of chickens of IV, V and VI groups compared to the I, II, III group under these conditions there was a significant increase in the content of urea, Ca, P, cholesterol, as well as albumin – only in IV group on the 48th day. Triacylglycerols’ content increased in the blood serum of chickens in III and IV groups compared to the II and V groups, but in V group – decreased compared to the III, IV groups. The increase in liver, thymus, and heart mass in the II and V chicken groups was noticed and their decrease in the VI group was revealed compared with the control group. Reliable lower coefficients of the body mass of chickens of III and VI groups may indicate a less notable stimulating biological effect of I, Se, S citrate in these doses on liver development than on the whole organism. The addition of I, Se, S citrate to broiler chickens during the period of growing revealed the difference in their biological action in the presence and absence of the Kokcisan 12% in a mixed fodder. A more notable stimulating effect of low dose of I, Se, S citrate on the growth and development on the chickens' organism was established during the withdrawal of coccidiostatics from their diet. The effect may be due to its inhibitory influence on the biological activity of these elements in the first 35 days of growing. In the final period of chicken growing and withdrawal of ionophore Kokcisan from the diet more noticeable changes were revealed in the studied parameters.
Aakre, I., Evensen, L. T., Kjellevold, M., Dahl, L., Henjum, S., Alexander, J., Madsen, L., & Markhus, M. W. (2020). Iodine status and thyroid function in a group of seaweed consumers in Norway. Nutrients, 12(11), 3483.
Antonyak, H. L., & Vlizlo, V. V. (2013). Biohimichna i geohimichna rol’ jodu [Biochemical and geochemical role of iodine]. Ivan Franko National University of Lviv, Lviv (in Ukrainian).
Beckett, G. J., & Arthur, J. R. (2005). Selenium and endocrine systems. Journal of Endocrinology, 184, 455–465.
Braden, K. W., Blanton, J. R., Allen, V. G., Pond, K. R., & Miller, M. F. (2004). Ascophyllum nodosum supplementation: A preharvest intervention for reducing Escherichia coli 0157:H7 and Salmonella spp. in feedlot steers. Journal of Food Protection, 67, 1824–1828.
Celi, P., Selle, P. H., & Cowieson, A. J. (2013). Effects of organic selenium supplementation on growth performance, nutrient utilisation, oxidative stress and selenium tissue concentrations in broiler chickens. Animal Production Science, 54, 966–971.
Chand, N., Faheem, H. H., Khan, R. U., Qureshi, M. S., Alhidary, I. A., & Abudabos, M. A. (2016). Anticoccidial effect of mananoligosacharide against experimentally induced coccidiosis in broiler. Environmental Science and Pollution Research, 23, 14414–14421.
Chandra, A. K., & Chakraborty, A. (2017). Influence of iodine in excess on seminiferous tubular structure and epididymal sperm character in male rats. Environmental Toxicology, 32, 1823–1835.
Chen, Y., Yang, Y., Liao, Q., Yang, W., Ma, W., Zhao, J., Zheng, X., Yang, Y., & Chen, R. (2016). Preparation, property of the complex of carboxymethyl chitosan grafted copolymer with iodine and application of it in cervical antibacterial biomembrane. Materials Science and Engineering: C, 67, 247–258.
Chun, I. L., Choe, H. S., Kang, C., Le, B. K., & Ryu, K. R. (2018). Effects of dietary organic sulfur on performance, egg quality and cell-mediated immune response of laying hens. Korean Journal of Poultry Science, 45(2), 97–107.
Cronan, J. E. (2018). Advances in synthesis of biotin and assembly of lipoic acid. Current Opinion in Chemical Biology, 47, 60–66.
Dierick, N., Ovyn, A., & De Smet, S. (2009). Effect of feeding intact brown seaweed Ascophyllum nodosum on some digestive parameters and on iodine content in edible tissues in pigs. Journal of the Science of Food and Agriculture, 89, 584–594.
Dolaychuk, O. P., Fedoruk, R. S., & Kropyvka, S. J. (2015). Physiological reactivity and antioxidant defense system of the animal organism induced by germanium, chromium, and selenium “nanoaquacitrates”. Agriculture Science and Practice, 2, 50–52.
Dolińska, B., Opaliński, S., Zieliński, M., Chojnacka, K., Dobrzański, Z., & Ryszka, F. (2011). Iodine concentration in fodder influences the dynamics of iodine levels in hen’s egg components. Biological Trace Element Research, 144, 747–752.
Drozdova, L. I., & Shatskikh, E. V. (2009). Sravnitel’naja morfologija immunnyh organov cypljat-brojlerov pri vozdejstvii razlichnyh preparatov selena i joda v rannem postembrional’nom periode [Comparative morphology of the immune organs of chicken broilers when exposed in the early post-embryonic period to different preparations of selenium and iodine]. Agrarnyj Vestnik Urala, 7, 73–75 (in Russian).
Duntas, L. H. (2010). Selenium and the thyroid: A close-knit connection. The Journal of Clinical Endocrinology and Metabolism, 95, 5180–5188.
Emara, S. (2019). Comparative effects of nano-selenium and sodium selenite supplementation on blood biochemical changes in relation to growth performance of growing New Zealand white rabbits. Arab Journal of Nuclear Sciences and Applications, 52(4), 1–14.
Faridi, A., Gitoee, A., Sakomura, N. K., Donato, D. C. Z., Gonsalves, C. A., Sarcinelli, M. F., Bernardino de Lima, M., & France, J. (2016). Broiler responses to digestible total sulphur amino acids at different ages: A neural network approach. Journal Applied Animal Research, 44(1), 315–322.
Fedoruk, R. S., Khrabko, M. I., & Dolaychuk, O. P. (2018). Effect of germanium citrate on the immunophysiological activity in rats. International Journal of Physiology and Pathophysiology, 9, 17–26.
Francioso, A., Conrado, A. B., Mosca, L., & Fontana, M. (2020). Chemistry and biochemistry of sulfur natural compounds: Key intermediates of metabolism and redox biology. Oxidative Medicine and Cellular Longevity, 2020, 8294158.
Gasparino, E., Del Vesco, A. P., Khatlab, A. S., Zancanela, V., Grieser, D. O., & Silva, S. C. C. (2018). Effects of methionine hydroxy analogue supplementation on the expression of antioxidant-related genes of acute heat stress-exposed broilers. Animal, 12, 931–939.
Halliwell, B., Cheah, I. K., & Tang, R. M. Y. (2018). Ergothioneine – a diet-derived antioxidant with therapeutic potential. FEBS Letters, 592(20), 3357–3366.
Hofmann, P., Siegert, W., Ahmadi, H., Krieg, J., Novotny, M., Naranjo, V. D., & Rodehutscord, M. (2020). Interactive effects of glycine equivalent, cysteine, and choline on growth performance, nitrogen excretion characteristics, and plasma metabolites of broiler chickens using neural networks optimized with genetic algorithms. Animals, 10, 1392.
Hunchak, A. V., & Ratych, I. B. (2014). Metabolichna i produktyvna dija jodu na organizm ptyci [Metabolic and productive action of iodine on the organism of birds]. Spolom, Lviv (in Ukrainian).
Iskra, R. Y., Vlizlo, V. V., & Fedoruk, R. S. (2017). Вiological efficiency of citrates of microelements in animal breeding. Agricultural Science and Practice, 4, 28–34.
Islamov, R., Kustova, T., Nersesyan, A., & Ilin, A. (2020). Subchronic toxicity of the new iodine complex in dogs and rats. Frontiers in Veterinary Science, 7, 184.
Joanta, A., Filip, A., Clichici, S., Andrei, S., & Daicoviciu, D. (2006). Iodide excess exerts oxidative stress in some target tissues of the thyroid hormones. Acta Physiologica Hungarica, 93, 347–359.
Kieronczyk, B., Sassek, M., Pruszynska-Oszmalek, E., Kolodziejski, P., Rawski, M., Swiatkiewicz, S., & Jozefiak, D. (2017). The physiological response of broiler chickens to the dietary supplementation of the bacteriocin nisin and ionophore coccidiostats. Poultry Science, 96, 4026–4037.
Kohrle, J., Jakob, F., Contempre, B., & Dumont, J. E. (2005). Selenium, the thyroid, and the endocrine system. Endocrine Reviews, 26, 944–984.
Landry, A. P., Ballou, D. P., & Banerjee, R. (2017). H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase. Journal of Biological Chemistry, 292(28), 11641–11649.
Lebsir, D., Manens, L., Grison, S., Lestaevel, P., Ebrahimian, T., Suhard, D., & Pech, A. (2018). Effects of repeated potassium iodide administration on genes involved in synthesis and secretion of thyroid hormone in adult male rat. Molecular and Cellular Endocrinology, 474, 119–126.
Leung, A. M., & Braverman, L. E. (2014) Consequences of excess iodine. Nature Reviews Endocrinology, 10, 136–142. http://doi.org/10.1038/nrendo.2013.251>
Liu, Z., Long, I. K., & Fryburg, D. (2006). The regulation of body and skeletal muscle protein metabolism by hormones and amino acids. The Journal of Nutrition, 136, 212–217.
Lu, C., & Cheng, S. Y. (2010). Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors. Journal Molecular Endocrinology, 44, 143–154.
Luger, D., Shinder, D., & Yahav, S. (2002). Hyper- or hypothyroidism: Its association with the development of ascites syndrome in fastgrowing chickens. General and Comparative Endocrinology, 127, 293–299.
Malavolta, M., & Mocchegiani, E. (Ed.). (2018). Trace elements and minerals in health and longevity. Springer Nature Switzerland.
Migues, P. V., Johnston, A. N. B., & Rose, S. P. R. (2002). Dehydroepiandrosterone and its sulphate enhance memory retention in day-old chicks. Neuroscience, 109, 243–251.
Milanesi, A., & Brent, G. A. (2017). Iodine and thyroid hormone synthesis, metabolism, and action. In: Collins, J. (Ed.). Molecular, genetic, and nutritional aspects of major and trace minerals. Academic Press. Pp. 143–150.
Mohapatra, P., Swain, R. K., Mishra, S. K., Behera, Z. T., Swain, Z. P., Mishra, Z. S. S., Behura, N. C., Sabat, S. C., Sethy, K., Dhama, K., & Jayasankar, Z. P. (2014). Effects of dietary nano-selenium on tissue selenium deposition, antioxidant status and immune functions in layer chicks. International Journal of Pharmacology, 10, 160–167.
Nys, Y., Schlegel, P., Durosoy, S., & Jondreville, C. (2018). Adapting trace mineral nutrition of birds for optimising the environment and poultry product quality. World’s Poultry Science Journal, 74(2), 225–238.
Oliva, T. V., & Gorshkov, G. I. (2014). Obogashhenie jodom i povyshenie pishhevoj cennosti produkcii pticevodstva: Mjasa i jaic [Enrichment by iodine and increase of the nutrition value of poultry-farming production: Meat and eggs]. Sovremennye Problemy Nauki i Obrazovanija, 5, 612–624 (in Russian).
Pajares, M. A., & Pérez-Sala, D. (2018). Mammalian sulfur amino acid metabolism: A nexus between redox regulation, nutrition, epigenetics, and detoxification. Antioxidants and Redox Signaling, 29(4), 408–452.
Pehrsson, P. R., Patterson, K. Y., Spungen, J. H., Wirtz, M. S., Andrews, K. W., Dwyer, J. T., & Swanson, C. A. (2016). Iodine in food and dietary supplement – composition databases. The American Journal of Clinical Nutrition, 104(3), 868–876.
Phan, G., Rebiere, F., Suhard, D., Legrand, A., Carpentier, F., Sontag, T., Souidi, M., Jourdain, J. R., Agarande, M., & Renaud-Salis, V. (2017). Optimal KI prophylactic dose determination for thyroid radiation protection after a single administration in adult rats. Dose-Response, 15(4), 1–8.
Ponomarenko, Y. A. (2014). Vlijanie razlichnyh doz joda i selena na produktivnost’ vyrashhivanija cypljat-brojlerov [Influence of various doses of iodine and selenium on the efficiency of growing chicken broilers]. Ptica i Pticeprodukti, 2, 48–50 (in Russian).
Rehman, A. U., Arif, M., Husnain, M. M., Alagawany, M., Abd El-Hack, M. E., Taha, A. E., Elnesr, S. S., Abdel-Latif, M. A., Othman, S. I., & Allam, A. A. (2019). Growth performance of broilers as influenced by different levels and sources of methionine plus cysteine. Animals, 9(12), 1056.
Samudovska, A., Demeterova, M., Skalicka, M., Bujnak, L., & Nad, P. (2018). Effect of water acidification on some morphological, digestive and production traits in broiler chickens. Bulgarian Journal of Veterinary Medicine, 21, 269–278.
Sarkar, D., Chakraborty, A., Saha, A., & Chandra, A. K. (2018). Iodine in excess in the alterations of carbohydrate and lipid metabolic pattern as well as histomorphometric changes in associated organs. Journal Basic Clin Physiology and Pharmacology, 29, 631–643.
Schomburg, L., & Köhrle, J. (2008). On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis. Molecular Nutrition and Food Research, 2, 1235–1246.
Smyth, P. P. A. (2003). Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors, 19, 121–130.
Song, Y., Yao, X., & Ying, H. (2011). Thyroid hormone action in metabolic regulation. Protein Cell, 2, 358–368.
Stojka, R. S. (Ed.). (2017). Bagatofunkcіonal’nі nanomaterіaly dlia bіologіji і medycyny: Molekuliarnyj dizajn, sintez і zastosuvannia [Multifunctional nanomaterials for biology and medicine: Molecular design, synthesis and application]. Naukova Dumka, Kyiv (in Ukrainian).
Strand, T. A., Lillegaard, I. T. L., Froyland, L., Haugen, M., Henjum, S., Lovik, M., Stea, T. H., & Holvik, K. (2018). Assessment of selenium intake in relation Totolerable upper intake levels. European Journal of Nutrition and Food Safety, 8(4), 155–156.
Surai, P. F., & Kochish, I. I. (2019). Nutritional modulation of the antioxidant capacities in poultry: The case of selenium. Poultry Science, 98(10), 4231–4239.
Surai, P. F., Kochish, I. I., Fisinin, V. I., & Velichko, O. A. (2018). Selenium in poultry nutrition: From sodium selenite to organic selenium sources. Journal Poultry Science, 55(2), 79–93.
Suzuki, R., Pacheco, L., Dorigam, J., Denadai, J., Viana, G., Varella, H., Nascimento, C., Milgen, J. V., & Sakomura, N. (2020). Stable isotopes to study sulfur amino acid utilization in broilers. Animal, 14(S2), 286–293.
Veeravalli, S., Phillips, I. R., Freire, R. T., Varshavi, D., Everett, J. R., & Shephard, E. A. (2020). Flavin-containing monooxygenase 1 catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48(5), 378–385.
Vlizlo, V. V., Fedoruk, R. S., & Ratych, I. B. (2012). Laboratorni metody doslidzhen u biologiji, tvarynnyctvi ta veterynarnij medycyni [Laboratory methods of investigation in biology, stock-breeding and veterinary medicine]. Spolom, Lviv (in Ukrainian).
Wang, H., Jiang, L., Wu, H., Zheng, W., Kan, D., Cheng, R., Yan, J., Yu, C., & Sun, S. (2019). Biocompatible iodine-starch-alginate hydrogel for tumor photothermal therapy. ACS Biomaterials Science Engineering, 5, 3654–3662.
Yausheva, E. V., Miroshnikov, S. A., Kosyan, D. B., & Sizova, Е. А. (2016). Nanoparticles in combination with amino acids change productive and immunological indicators of broiler chicken. Agricultural Biology, 51, 912–920.
Yuldasheva, G. A., Zhidomirov, G. M., Abekova, A. O., & Ilin, A. I. (2016). The mechanism of anti-cancer activity of complexes of molecular iodine with a-dextrins and polypeptides and lithium halogenides. Journal Antivir Antiretroviral, 8, 72–78.
Zimmermann, M. B., & Boelaert, K. (2015). Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinology, 3(4), 286–295.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons «Attribution» 4.0 License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.