Application of correlation analysis in cytology: Opportunities to study specific activity of follicular thyrocytes
AbstractThe task of biomedical diagnostics is to determine the dependence of the conclusion/diagnosis on the sets of parameters that characterize the state of the biosystem/patient. The performed analytical review of modern scientific literature permitted us to determine that Bayesian, regression and correlation analyzes and logical programming are most often used for biomedical diagnostics purposes. At the same time, their informativeness can only be realized for the solution of those diagnostic tasks in which quantitative parameters are analyzed. Qualitative and binary information provides an opportunity to find out more about features of the biosystem’s state. However, its use is limited, since the results obtained are presented in words (that is, in a linguistic form) that cannot be processed by means of traditional (digital) mathematical analysis. The objective of this work was determining the capabilities of the mathematical apparatus to deepen the study of hormonopoiesis in the thyroid gland. The object of the study was electron micrographs of ultrathin tissue sections, its subject was the features of correlations between ultrastructural cell elements which carry out the processes of synthesis and secretion in follicular thyrocytes. In the context of studying the features of synthetic and secretory activity of follicular thyrocytes of the thyroid glands in white male rats, it was shown that the objectification of non-numerical information about the state of cells allows us to use linguistic information about changes in their morphofunctional state. Implementation of correlation analysis for studying the relationships and interdependencies between organelles which implement synthesis and secretion of the hormonal product in the main structural unit of the thyroid gland – follicular thyrocyte – allows us to determine, study, analyze and generalize peculiarities of both changes in individual ultrastructures and their functional complexes (clusters) in response to the actions of various factors and to trace the interdependencies and mutual interactions existing between them, as well as to deepen the idea of the intimate mechanism features of the specific directions of follicular thyrocyte activity, which substantially expands the research platform in cytophysiology and cytomorphology.
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