Biotechnological charactheristic of catheterized urinary tract as flow system

  • V. P. Zhalko-Tytarenko State Institution “L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases of NAMS of Ukraine”
  • E. A. Synetar 1State Institution “L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases of NAMS of Ukraine”
  • S. I. Savoschenko Kyiv City Clinical Hospital N 6
Keywords: catheter-associated infections, silicone catheter, adhesion, biofilms


It is well known that the ureter of mammals and man works as a flow system that normally remains uninfected. In biotechnology flow systems are used to produce microbial mass on orders greater than when grown in laboratory and industrial periodic cultures. Therefore, these systems are used in the microbiological industry. But there ina flow systems one can observe a growth in microbial populations, the patterns of which can be fruitful in studying the process of catheter-associated urinary tract infections. The main factors are the speed of propagation and speed of flow, and their variation in conditions of the catheterized urinary tract, which determines the magnification factor of microbial infection. In this lies the general biological need to study them from a biotechnology perspective. Hence the question arises – why are there changes in the flow system of the urinary tract during catheterization, which contribute to the reproduction of opportunistic microorganisms, as a factor of infection? In the study of the biological properties of agents of catheter-associated infections this issue has not attracted sufficient attention from researchers. In view of the above, the purpose of our study was to establish patterns of population growth of agents of urinary tract infections on the model of the yeast fungus species Candida albicans (C.P. Robin) Berkhout, 1923 in the catheterized human urinary tract, treated as a flow system. The results of the research show that the emergence of catheter-associated urinary tract infections is a regularity inherent throughout the flow system. It was proved that with the model C. albicans, bacteria in urine multiply faster than in the medium Saburo. The study established that one of the factors leading to catheter-associated urinary tract infections is the persistent presence of urine deposits around the head of the catheter in the bladder, which provides bacteria with sufficient conditions for reproduction and where bacteria cannot be eliminated by urine flow. When the pathogen enters and reproduces in the bladder, the latter is a reservoir of infection like a "royal culture", with a gradual overgrowth in the catheter of yeast fungi of the species C. albicans. These data suggest that the mechanism of strengthening catheter-associated urinary tract infections are the formation of biofilms by microorganisms around the catheter head and on its surfaces. It is recommended to further improve the design of urinal catheters in such a way that ensures the complete emptying of the bladder and avoidance of urethral reflux.


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How to Cite
Zhalko-Tytarenko, V. P., Synetar, E. A., & Savoschenko, S. I. (2016). Biotechnological charactheristic of catheterized urinary tract as flow system. Regulatory Mechanisms in Biosystems, 7(1), 53–58.