Impact of maternal age, thyroid function, and vitamin D status on in vitro fertilization outcomes

R. H. Jawad; D. Masheta

doi:10.15421/0226102

R. H. Jawad University of Babylon
D. Masheta University of Babylon

Keywords: in vitro fertilization, thyroid stimulating hormone, vitamin D, age, infertility, implantation, assisted reproductive technology.

Abstract

In vitro fertilization (IVF) is one of the most effective assisted reproductive technologies for the treatment of infertility. Ho w ever, despite substantial technological advancements, IVF success rates remain limited, and implantation failure continues to represent a significant clinical challenge. Hormonal balance plays a crucial role in female reproductive physiology. The present study aimed to evaluate the association between prolactin, thyroid function, reproductive hormones, anthropometric parameters, and IVF success. The cross-sectional study included 101 women undergoing IVF treatment in Tiba IVF Center , Hilla city, Iraq, from November 2025 to March 2026 , comprising 60 successful IVF cases and 41 failed IVF cases. Serum TSH and 25-hydroxyvitamin D levels were measured. The results indicated that the mean age was significantly higher in the failed IVF group compared with the successful IVF group (30.33 ± 6.00 vs 28.19 ± 4.91 years). Similarly, mean serum TSH levels were signif i cantly elevated in the failed IVF group (2.8 ± 1.1 µIU/mL) compared with the successful group (1.9 ± 0.9 µIU/mL). In contrast, serum vitamin D levels showed no statistically significant difference between successful and failed IVF groups (15.46 ± 11.27 vs 17.69 ± 11.83 ng/mL). Also, BMI, height, or weight shown to have no significant association. The study indicated that maternal age and serum TSH levels were significantly associated with IVF outcome, whereas vitamin D levels and anthropometric mea s urements were not.

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