Effect of autologous platelet-rich plasma on gastric wall regeneration after experimental gastrotomy in rabbits

  • D. O. Kovalenko National University of Life and Environmental Sciences of Ukraine
  • M. O. Malyuk National University of Life and Environmental Sciences of Ukraine
  • V. V. Klymchuk National University of Life and Environmental Sciences of Ukraine
  • O. V. Onyshchenko National University of Life and Environmental Sciences of Ukraine
  • V. V. Honchar National University of Life and Environmental Sciences of Ukraine
  • V. V. Tkachenko National University of Life and Environmental Sciences of Ukraine
  • I. M. Gorkava National University of Life and Environmental Sciences of Ukraine
DOI: https://doi.org/10.15421/0226026
Keywords: platelet-rich plasma, gastric wall regeneration, experimental gastrotomy, rabbits, histological studies, smooth muscle tissue regeneration.

Abstract

The aim of the study was to determine the effect of autologous platelet-rich plasma on the processes of regeneration of the gastric wall in rabbits after experimental gastrotomy . The study was conducted on 62 Chinchilla breed rabbits, which were divi d ed into a control group and an experimental group. Animals of the experimental group underwent infiltration of the gastric wall suture with autologous platelet-rich plasma, whereas animals of the control group received standard therapy. Morphological changes in gastric tissues were evaluated histologically on the 1st, 3rd, 7th, 10th, 14th, and 21st days after surgery. It was esta b lished that the use of autologous platelet-rich plasma contributed to a more intensive contraction of the gastric muscular layer at the early stages of healing, which ensured faster wound closure and a reduction in the effect of gastric juice on the tissues. An i mals of the experimental group exhibited a less pronounced inflammatory reaction, improved blood supply, and active prolifer a tion of smooth muscle tissue cells. As early as the 7th day, the structure of the muscular and serosal layers in the area of surgical intervention was similar to that of intact tissues. Complete regeneration of all layers of the gastric wall in animals of the exper i mental group was observed on the 10th–14th day, whereas in the control group this process was completed only on the 21st day. The obtained results indicate that the use of autologous platelet-rich plasma significantly accelerates the regenerative processes of the gastric wall after gastrotomy and may be an effective method for optimizing postoperative healing in veterinary surgery.

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Published
2026-02-26
How to Cite
Kovalenko, D. O., Malyuk, M. O., Klymchuk, V. V., Onyshchenko, O. V., Honchar, V. V., Tkachenko, V. V., & Gorkava, I. M. (2026). Effect of autologous platelet-rich plasma on gastric wall regeneration after experimental gastrotomy in rabbits. Regulatory Mechanisms in Biosystems, 17(2), e26026. https://doi.org/10.15421/0226026
Issue
Vol 17 No 2 (2026): Regulatory Mechanisms in Biosystems
Section
Статті

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