Association of TCF7L2 gene expression with clinical and biochemical markers in type 2 diabetes mellitus patients in Babylon Province
Abstract
T2DM is a long-term, progressive metabolic disease characterized by elevated blood glucose levels brought on by insulin resistance and a decline in pancreatic β-cell function. Our r esearch aimed to examine the correlation between the levels of parameters (FBS, HbA1c, TG, TC, HDL, LDL, and VLDL) and the genetic expression of the TCF7L2 gene in patients with T2DM (G2) in comparison to the control group (G1). There were 200 participants in the study: 100 patients with T2DM (G2) and 100 ethnically matched controls (G1). The T2DM patients were nonsmok ers between the ages of 45 and 60 who attended the Marjan Teaching Hospital, Specialized Diabetes Center in Babylon Governorate, Iraq . Together with the genetic expression analysis of the TCF7L2 gene, which was confirmed to be pertinent to the clinical symptoms and biochemical features of the present investigation, specific tests were performed for the biochemical parameters of FBS, HbA1c, TG, TC, HDL, LDL, and VLDL. The study found that the re was a significant difference between the two study groups in the levels of FBS, HbA1c, TC, and the gene expression level of the TCF7L2 gene. T he mean values for the parameters of FBS, HbA1c, TC, HDL, LDL and VLDL were high in the T2DM group (G2) compared to the control group (G1). B y studying the Pearson correlation, a correlation was found between FBS and HbA1c, between FBS and TG, and between HbA1c and TG, where the Pearson correlation value was signif i cant . The study concluded that low gene expression of TCF72 is associated with high FBS, HbA1c, and TG levels in patients with T2DM, and that there is a correlation between clinical parameters in patients with T2DM . .References
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