Hyaluronic acid: Innovations and prospects in biology and medicine

A. A. Seliuta; A. L. Polyakova; T. M. Gurina

doi:10.15421/0225167

A. A. Seliuta Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
A. L. Polyakova Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
T. M. Gurina Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine

Keywords: molecular weight, regeneration, wound healing, hydrogel, cryopreservation.

Abstract

Hyaluronic acid (HA) is a natural glycosaminoglycan found in all tissues and body fluids of vertebrates, including those of humans. Its biological functions vary with molecular weight. As the main component of the extracellular matrix, HA, owing to its high water-binding capacity, plays a critical role in maintaining tissue hydration, osmotic balance, lubrication, and cellular activity. It influences cell proliferation, differentiation and migration, inflammation, immunomodulation, angiogenesis, and other biological processes. This article reviews recent advances in HA applications across regenerative medicine, orthopedics, derma tology, neurology, dentistry, cosmetology, cryobiology, drug delivery, oncology, and the food industry. E ffectiveness of HA in wound healing depends largely on its molecular weight: high molecular weight HA exhibits immunosuppressive and anti-inflammatory effects, whereas low molecular weight HA promotes immunostimulation and amplifies inflammation. Hydrogels based on HA and its derivatives have gained prominence as potential treatments for bone diseases. Advances in 3D printing enable precise control of scaffold architecture and porosity, which is essential for mimicking native bone tissue, and allow int e gration of HA-based hydrogels with other materials to generate composite scaffolds with enhanced performance. In dentistry, HA is commonly used for diverse procedures, including papilla regeneration injections, implant coating, topical treatment of oral ulcers, supplementation to platelet-rich fibrin, plasma and growth factors, use as a matrix for encapsulation of stem cells and signalling molecules and as a nanocarrier of drugs, and therapy of denture- or surgery-induced stomatitis and irritation. In op h thalmology, HA is used in eye drops to relieve eye dryness and to improve contact lens tolerance. Due to its viscosity, HA is useful in various ophthalmic procedures, including cataract surgery, vitreoretinal surgery and glaucoma treatment. In cryobiol o gy, HA is being explored as part of complex cryoprotectant formulations. For example, HA is known to be able to neutralize free radicals and to protect cells from reactive oxygen species generated by cryoprotectants. The article also highlights prospects for the rising use of innovative HA-based products to advance current medical practices and biotechnologies.

References

Al-Halaseh, L. K., Al-Jawabri, N. A., Tarawneh, S. K., Al-Qdah, W. K., Abu-Hajleh, M. N., Al-Samydai, A. M., & Ahmed, M. A. (2022). A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid. Journal of Applied Pharmaceutical Science, 12(07), 34–41.

Al-Hilifi, S. A., Al-Ali, R. M., Dinh, L. N. M., Yao, Y., & Agarwal, V. (2024). Development of hyaluronic acid based polysaccharide-protein composite edible coatings for preservation of strawberry fruit. International Journal of Biological Macromolecules, 259(1), 128932.

Al-Khateeb, R., & Olszewska-Czyz, I. (2020). Biological molecules in dental applications: Hyaluronic acid as a companion biomaterial for diverse dental applications. Heliyon, 6(4), e03722.

Altman, R., Bedi, A., Manjoo, A., Niazi, F., Shaw, P., & Mease, P. (2019). Anti-inflammatory effects of intra-articular hyaluronic acid: A systematic review. Cartilage, 10(1), 43–52.

Apaolaza, P. S., Busch, M., Asin-Prieto, E., Peynshaert, K., Rathod, R., Remaut, K., Dünker, N., & Göpferich, A. (2020). Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution. Experimental Eye Research, 198, 108151.

Arısoy, S., Bux, K., Herwig, R., & Şalva, E. (2024). Development, evaluation, and molecular dynamics study of ampicillin-loaded chitosan-hyaluronic acid films as a drug delivery system. ACS Omega, 9(18), 19805–19815.

Barroso, A., Mestre, H., Ascenso, A., Simões, S., & Reis, C. (2020). Nanomaterials in wound healing: From material sciences to wound healing applications. Nano Select, 1, 443–460.

Bhattacharyya, M., Jariyal, H., & Srivastava, A. (2023). Hyaluronic acid: More than a carrier, having an overpowering extracellular and intracellular impact on cancer. Carbohydrate Polymers, 317, 121081.

Buckley, C., Murphy, E. J., Montgomery, T. R., & Major, I. (2022). Hyaluronic acid: A review of the drug delivery capabilities of this naturally occurring polysaccharide. Polymers, 14(17), 3442.

Bui, H. D., Cho, W., Park, J. K., Lee, M. S., Kim, H. K., & Yoo, H. S. (2023). Korean amberjack skin-inspired hyaluronic acid bioink for reconstruction of human skin. ACS Omega, 8(25), 22752–22761.

Campo, G. M., Avenoso, A., Campo, S., D'Ascola, A., Traina, P., Samà, D., & Calatroni, A. (2008). NF-kB and caspases are involved in the hyaluronan and chondroitin-4-sulphate-exerted antioxidant effect in fibroblast cultures exposed to oxidative stress. Journal of Applied Toxicology, 28(4), 509–517.

Canciani, E., Sirello, R., Pellegrini, G., Henin, D., Perrotta, M., Toma, M., Khomchyna, N., & Dellavia, C. (2021). Effects of vitamin and amino acid-enriched hyaluronic acid gel on the healing of oral mucosa: In vivo and in vitro study. Medicina, 57(3), 285.

Caon, I., Bartolini, B., Parnigoni, A., Caravà, E., Moretto, P., Viola, M., Karousou, E., Vigetti, D., & Passi, A. (2020). Revisiting the hallmarks of cancer: The role of hyaluronan. Seminars in cancer biology, 62, 9–19.

Chang, J. W., Koo, W. Y., Kim, E. K., Lee, S. W., & Lee, J. H. (2020). Facial rejuvenation using a mixture of calcium hydroxylapatite filler and hyaluronic acid filler. The Journal of Craniofacial Surgery, 31(1), e18–e21.

Cho, W., Park, Y., Jung, Y. M., Park, J. H., Park, J., & Yoo, H. S. (2022). Electrospun nanofibrils surface-decorated with photo-cross-linked hyaluronic acid for cell-directed assembly. ACS Omega, 7(44), 40355–40363.

Chylińska, N., & Maciejczyk, M. (2025). Hyaluronic acid and skin: Its role in aging and wound-healing processes. Gels, 11(4), 281.

Collins, M. N., & Birkinshaw, C. (2013). Hyaluronic acid based scaffolds for tissue engineering – a review. Carbohydrate Polymers, 92(2), 1262–1279.

Cui, N., Qian, J., Liu, T., Zhao, N., & Wang, H. (2015). Hyaluronic acid hydrogel scaffolds with a triple degradation behavior for bone tissue engineering. Carbohydrate Polymers, 126, 192–198.

Curcio, M., Vittorio, O., Bell, J. L., Iemma, F., Nicoletta, F. P., & Cirillo, G. (2022). Hyaluronic acid within self-assembling nanoparticles: Endless possibilities for targeted cancer therapy. Nanomaterials, 12(16), 2851.

Dovedytis, M., Liu, Z., & Bartlett, S. (2020). Hyaluronic acid and its biomedical applications: A review. Engineered Regeneration, 12, 102–113.

Fallacara, A., Baldini, E., Manfredini, S., & Vertuani, S. (2018). Hyaluronic acid in the third millennium. Polymers, 10(7), 701.

Frost, S. J., & Weigel, P. H. (1990). Binding of hyaluronic acid to mammalian fibrinogens. Biochimica et Biophysica Acta, 1034(1), 39–45.

Hanjaya-Putra, D., Bose, V., Shen, Y. I., Yee, J., Khetan, S., Fox-Talbot, K., Steenbergen, C., Burdick, J. A., & Gerecht, S. (2011). Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. Blood, 118(3), 804–815.

Hauck, S., Zager, P., Halfter, N., Wandel, E., Torregrossa, M., Kakpenova, A., Rother, S., Ordieres, M., Räthel, S., Berg, A., Möller, S., Schnabelrauch, M., Simon, J. C., Hintze, V., & Franz, S. (2021). Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity. Bioactive Materials, 6(12), 4342–4359.

Heron, M. (2019). Deaths: Leading causes for 2017. National Vital Statistics Reports, 68(6), 1–77.

Hinneh, J. A., Gillis, J. L., Moore, N. L., Butler, L. M., & Centenera, M. M. (2022). The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities. Frontiers in Oncology, 12, 982231.

Hwang, H. S., & Lee, C. S. (2023). Recent progress in hyaluronic-acid-based hydrogels for bone tissue engineering. Gels, 9(7), 588.

Iaconisi, G. N., Lunetti, P., Gallo, N., Cappello, A. R., Fiermonte, G., Dolce, V., & Capobianco, L. (2023). Hyaluronic acid: A powerful biomolecule with wide-ranging applications – a comprehensive review. International Journal of Molecular Sciences, 24(12), 10296.

Iviglia, G., Kargozar, S., & Baino, F. (2019). Biomaterials, current strategies, and novel nano-technological approaches for periodontal regeneration. Journal of Functional Biomaterials, 10(1), 3.

Jensen, G., Holloway, J. L., & Stabenfeldt, S. E. (2020). Hyaluronic acid biomaterials for central nervous system regenerative medicine. Cells, 9(9), 2113.

Jiang, M., Yang, S., Ren, Q., Hu, D., Lu, Z., Liu, Z., & Li, Z. (2025). Glycosaminoglycans in hard tissue repair and regeneration: A group of re-emerging natural carbohydrates. Carbohydrate Polymers, 366, 123867.

Kang, L. J., Yoon, J., Rho, J. G., Han, H. S., Lee, S., Oh, Y. S., Kim, H., Kim, E., Kim, S. J., Lim, Y. T., Park, J. H., Song, W. K., Yang, S., & Kim, W. (2021). Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment. Biomaterials, 275, 120967.

Kaul, A., Short, W. D., Keswani, S. G., & Wang, X. (2021). Immunologic roles of hyaluronan in dermal wound healing. Biomolecules, 11(8), 1234.

Khaeruddin, K., Wahjuningsih, S., Ciptadi, G., Yusuf, M., Hermawansyah, H., & Sahiruddin, S. (2022). Cryopreservation of Gaga' chicken semen from South Sulawesi, Indonesia with the addition of L-carnitine, hyaluronic acid, sucrose and their combination in diluent. Biodiversitas Journal of Biological Diversity, 23(6), 3297–3302.

Kim, J. W., Han, Y. S., Lee, H. M., Kim, J. K., & Kim, Y. J. (2021). Effect of morphological characteristics and biomineralization of 3D-printed gelatin / hyaluronic acid/hydroxyapatite composite scaffolds on bone tissue regeneration. International Journal of Molecular Sciences, 22(13), 6794.

Knudson, W., Ishizuka, S., Terabe, K., Askew, E. B., & Knudson, C. B. (2019). The pericellular hyaluronan of articular chondrocytes. Matrix Biology, 78–79, 32–46.

Kobayashi, T., Chanmee, T., & Itano, N. (2020). Hyaluronan: metabolism and function. Biomolecules, 10(11), 1525.

Kolaříková, A., Kutálková, E., Hrnčiřík, J., & Ingr, M. (2024). Hyaluronan oligosaccharides form double-helical duplexes in water: 1,4-Dioxane mixed solvent. Carbohydrate Polymers, 326, 121632.

Kotla, N. G., Bonam, S. R., Rasala, S., Wankar, J., Bohara, R. A., Bayry, J., Rochev, Y., & Pandit, A. (2021). Recent advances and prospects of hyaluronan as a multifunctional therapeutic system. Journal of Controlled Release, 336, 598–620.

Kuppa, S. S., Kang, J. Y., Yang, H. Y., Lee, S. C., Sankaranarayanan, J., Kim, H. K., & Seon, J. K. (2024). Hyaluronic acid viscosupplement modulates inflammatory mediators in chondrocyte and macrophage coculture via MAPK and NF-κB signaling pathways. ACS Omega, 9(19), 21467–21483.

Laradji, A. M., Kolesnikov, A. V., Karakoçak, B. B., Kefalov, V. J., & Ravi, N. (2021). Redox-responsive hyaluronic acid-based nanogels for the topical delivery of the visual chromophore to retinal photoreceptors. ACS Omega, 6(9), 6172–6184.

Lei, C., Liu, X. R., Chen, Q. B., Li, Y., Zhou, J. L., Zhou, L. Y., & Zou, T. (2021). Hyaluronic acid and albumin based nanoparticles for drug delivery. Journal of Controlled Release, 331, 416–433.

Li, Y., Xu, T., Tu, Z., Dai, W., Xue, Y., Tang, C., Gao, W., Mao, C., Lei, B., & Lin, C. (2020). Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair. Theranostics, 10(11), 4929–4943.

Lierova, A., Kasparova, J., Filipova, A., Cizkova, J., Pekarova, L., Korecka, L., Mannova, N., Bilkova, Z., & Sinkorova, Z. (2022). Hyaluronic acid: Known for almost a century, but still in vogue. Pharmaceutics, 14(4), 838.

Lierova, A., Kasparova, J., Pejchal, J., Kubelkova, K., Jelicova, M., Palarcik, J., Korecka, L., Bilkova, Z., & Sinkorova, Z. (2020). Attenuation of radiation-induced lung injury by hyaluronic acid nanoparticles. Frontiers in Pharmacology, 11, 1199.

Liu, M., Tolg, C., & Turley, E. (2019). Dissecting the dual nature of hyaluronan in the tumor microenvironment. Frontiers in Immunology, 10, 947.

Liu, Y., Chen, D., Zhang, A., Xiao, M., Li, Z., Luo, W., Pan, Y., Qu, W., & Xie, S. (2021). Composite inclusion complexes containing hyaluronic acid / chitosan nanosystems for dual responsive enrofloxacin release. Carbohydrate Polymers, 252, 117162.

Long, C., Peng, H., Yang, W., Wang, M., Luo, B., Hao, J., Dong, Y., & Zuo, W. (2024). Targeted delivery of gemcitabine for precision therapy of cholangiocarcinoma using hyaluronic acid-modified metal-organic framework nanoparticles. ACS Omega, 9(10), 11998–12005.

Mansour, A., Acharya, A. B., Alliot, C., Eid, N., Badran, Z., Kareem, Y., & Rahman, B. (2024). Hyaluronic acid in dentoalveolar regeneration: Biological rationale and clinical applications. Journal of Oral Biology and Craniofacial Research, 14(2), 230–235.

Matsiko, A., Levingstone, T. J., O'Brien, F. J., & Gleeson, J. P. (2012). Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials, 11, 41–52.

Monteiro, I. P., Shukla, A., Marques, A. P., Reis, R. L., & Hammond, P. T. (2015). Spray-assisted layer-by-layer assembly on hyaluronic acid scaffolds for skin tissue engineering. Journal of Biomedical Materials Research, Part A, 103(1), 330–340.

Munesada, D., Sakai, D., Nakamura, Y., Schol, J., Matsushita, E., Tamagawa, S., Sako, K., Ogasawara, S., Sato, M., & Watanabe, M. (2023). Investigation of the mitigation of DMSO-induced cytotoxicity by hyaluronic acid following cryopreservation of human nucleus pulposus cells. International Journal of Molecular Sciences, 24(15), 12289.

Musiał, C. (2021). Rola i zastosowanie glikozaminoglikanów w trychologii i kosmetologii [Role and application of glycosaminoglycans in trichology and cosmetology]. Aesthetic Cosmetology and Medicine, 10(1), 33–37 (in Polish).

Nagy, N., Kuipers, H. F., Marshall, P. L., Wang, E., Kaber, G., & Bollyky, P. L. (2019). Hyaluronan in immune dysregulation and autoimmune diseases. Matrix Biology, 78–79, 292–313.

Nör, J. E., Peters, M. C., Christensen, J. B., Sutorik, M. M., Linn, S., Khan, M. K., Addison, C. L., Mooney, D. J., & Polverini, P. J. (2001). Engineering and characterization of functional human microvessels in immunodeficient mice. Laboratory Investigation, 81(4), 453–463.

Parmal, S., Subbappa, P., Nikam, V., Tarwate, Y., Barhate, K., Wagh, S., Gholap, A. D., Dua, K., Singh, S. K., Parikh, D., Shaikh, M., Khan, T. K., & Rajput, A. (2025). Hyaluronic acid based approaches for wound healing: A comprehensive review. International Journal of Biological Macromolecules, 306(4), 141625.

Patel, M., & Koh, W. G. (2020). Composite hydrogel of methacrylated hyaluronic acid and fragmented polycaprolactone nanofiber for osteogenic differentiation of adipose-derived stem cells. Pharmaceutics, 12(9), 902.

Patil, S. C., Dhalkari, C. D., & Indurkar, M. S. (2020). Hyaluronic acid: Ray of hope for esthetically challenging black triangles: A case series. Contemporary Clinical Dentistry, 11(3), 280–284.

Petit, N., Chang, Y. J., Lobianco, F. A., Hodgkinson, T., & Browne, S. (2025). Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations. Materials Today, Bio, 31, 101596.

Qian, L., Yu, S., & Zhou, Y. (2016). Protective effect of hyaluronic acid on cryopreserved boar sperm. International Journal of Biological Macromolecules, 87, 287–289.

Quartey, B. C., Sapudom, J., ElGindi, M., Alatoom, A., & Teo, J. (2024). Matrix-bound hyaluronan molecular weight as a regulator of dendritic cell immune potency. Advanced Healthcare Materials, 13(8), e2303125.

Rao, N. V., Rho, J. G., Um, W., Ek, P. K., Nguyen, V. Q., Oh, B. H., Kim, W., & Park, J. H. (2020). Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases. Pharmaceutics, 12(10), 931.

Rodella, G., Préat, V., Gallez, B., & Malfanti, A. (2025). Design strategies for hyaluronic acid-based drug delivery systems in cancer immunotherapy. Journal of Controlled Release, 383, 113784.

Sánchez, D. C., Ocampo, B. R. Y., & Chirino, C. A. E. (2017). Use of hyaluronic acid as an alternative for reconstruction of interdental papilla. Revista Odontológica Mexicana, 21(3), 199–207.

Sapudom, J., Müller, C. D., Nguyen, K. T., Martin, S., Anderegg, U., & Pompe, T. (2020). Matrix remodeling and hyaluronan production by myofibroblasts and cancer-associated fibroblasts in 3D collagen matrices. Gels, 6(4), 33.

Scheuer, C. A., Rah, M. J., & Reindel, W. T. (2016). Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution. Clinical Ophthalmology, 10, 1945–1952.

Senbanjo, L. T., & Chellaiah, M. A. (2017). CD44: A multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cells. Frontiers in Cell and Developmental Biology, 5, 18.

Shahi, M., Mohammadnejad, D., Karimipour, M., Rasta, S. H., Rahbarghazi, R., & Abedelahi, A. (2020). Hyaluronic acid and regenerative medicine: New insights into the stroke therapy. Current Molecular Medicine, 20(9), 675–691.

Silvani, L., Bedei, A., De Grazia, G., & Remiddi, S. (2020). Arabinogalactan and hyaluronic acid in ophthalmic solution: Experimental effect on xanthine oxidoreductase complex as key player in ocular inflammation (in vitro study). Experimental Eye Research, 196, 108058.

Singampalli, K. L., Balaji, S., Wang, X., Parikh, U. M., Kaul, A., Gilley, J., Birla, R. K., Bollyky, P. L., & Keswani, S. G. (2020). The role of an IL-10 / hyaluronan axis in dermal wound healing. Frontiers in Cell and Developmental Biology, 8, 636.

Singha, N. C., Nekoroski, T., Zhao, C., Symons, R., Jiang, P., Frost, G. I., Huang, Z., & Shepard, H. M. (2015). Tumor-associated hyaluronan limits efficacy of monoclonal antibody therapy. Molecular Cancer Therapeutics, 14(2), 523–532.

Slevin, M., Krupinski, J., Gaffney, J., Matou, S., West, D., Delisser, H., Savani, R. C., & Kumar, S. (2007). Hyaluronan-mediated angiogenesis in vascular disease: Uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biology, 26(1), 58–68.

Sudhakar, K., Ji, S. M., Kummara, M. R., & Han, S. S. (2022). Recent progress on hyaluronan-based products for wound healing applications. Pharmaceutics, 14(10), 2235.

Sun, W., Schaffer, S., Dai, K., Yao, L., Feinberg, A., & Webster-Wood, V. (2021). 3D printing hydrogel-based soft and biohybrid actuators: A mini-review on fabrication techniques, applications, and challenges. Frontiers in Robotics and AI, 8, 673533.

Tallapaneni, V., Pamu, D., Shilpa, T. N., Karri, V. V. S. R., & Mohankumar, S. K. (2021). Chapter 6 – Emerging role of inorganic and metal nanoparticles for the delivery of combination of drugs in wound healing and tissue regeneration. In: Baboota, S., & Ali, J. (Eds.). Nanocarriers for the delivery of combination drugs. Elsevier. Pp. 195–226.

Tavakoli, S., Krishnan, A., Mokhtari, H., Oommen, O. P., & Varghese, O. P. (2023). Fine-tuning dynamic cross-linking for enhanced 3D bioprinting of hyaluronic acid hydrogels. Advanced Functional Materials, 34, 2307040.

Tolg, C., Messam, B. J., McCarthy, J. B., Nelson, A. C., & Turley, E. A. (2021). Hyaluronan functions in wound repair that are captured to fuel breast cancer progression. Biomolecules, 11(11), 1551.

Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B. (2020). Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, 12(8), 735.

Townsend, J. M., Andrews, B. T., Feng, Y., Wang, J., Nudo, R. J., Van Kampen, E., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2018). Superior calvarial bone regeneration using pentenoate-functionalized hyaluronic acid hydrogels with devitalized tendon particles. Acta Biomaterialia, 71, 148–155.

Valachová, K., & Šoltés, L. (2021). Hyaluronan as a prominent biomolecule with numerous applications in medicine. International Journal of Molecular Sciences, 22(13), 7077.

Wang, M., Deng, Z., Guo, Y., & Xu, P. (2022). Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering. Materials Today, Bio, 17, 100495.

Wang, X., Liu, X., Li, C., Li, J., Qiu, M., Wang, Y., & Han, W. (2025). Effects of molecular weights on the bioactivity of hyaluronic acid: A review. Carbohydrate Research, 552, 109472.

Wu, W., Jiang, H., Guo, X., Wang, Y., Ying, S., Feng, L., Li, T., Xia, H., Zhang, Y., Chen, R., Chen, T., & Lou, J. (2017). The protective role of hyaluronic acid in Cr(VI)-induced oxidative damage in corneal epithelial cells. Journal of Ophthalmology, 2017, 3678586.

Yang, H., Song, L., Zou, Y., Sun, D., Wang, L., Yu, Z., & Guo, J. (2021). Role of hyaluronic acids and potential as regenerative biomaterials in wound healing. ACS Applied Bio Materials, 4(1), 311–324.

Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., & Cui, H. (2020). Targeting cancer stem cell pathways for cancer therapy. Signal Transduction and Targeted Therapy, 5(1), 8.

Yuan, H., Xiao, P., Sarmento, B., Chen, G., & Cui, W. (2024). Synovial lubrication factors-recruiting biomimetic polyphenolized hyaluronic acid for promoting cartilage repair. Advanced Functional Materials, 34(42), 2406668.

Zhai, P., Peng, X., Li, B., Liu, Y., Sun, H., & Li, X. (2020). The application of hyaluronic acid in bone regeneration. International Journal of Biological Macromolecules, 151, 1224–1239.

Zhang, W., Liu, Y., Zhang, L., & Shen, X. (2025). Development of hyaluronic acid-based hydrogels for chronic diabetic wound healing: A review. International Journal of Biological Macromolecules, 308(1), 142273.

Zhu, C., Fan, D., & Wang, Y. (2014). Human-like collagen/hyaluronic acid 3D scaffolds for vascular tissue engineering. Materials Science and Engineering, C, Materials for Biological Applications, 34, 393–401.