The current application of commonly available fruit wastes for the synthesis of polyhydroxyalkanoates from bacteria
Abstract
The rapid depletion of fossil fuel and its hazardous effect on the environment encourages research on the synthesis of bi o based plastics such as polyhydroxyalkanoates (PHAs) for the replacement of traditional plastics. Polyhydroxyalkanoates (PHA s ) are intracellularly synthesized biopolymer s that are non-toxic and biologically degradable in nature. Their physicochemical and mechanical properties are mostly similar to petrochemically derived plastics. A major limitation of the commercialization of polyhydroxyalkanoates is the high cost in comparison with petroleum-derived polymers. A lot of research is in progress towards searching for the cheapest carbon source for the culture of bacteria. Among various carbon sources available , biosynthesis of PHA from fruit wastes is still in its initial stage and several challenges remain to be resolved. In order to increase the availability of fermentable sugars and increase microbial intake, screening of more fruit waste materials and substrate pre-treatment proc e dures must be improved. For PHA recovery and purification, the development of effective and economical downstream processing methods is an additional area that needs focus. The economic feasibility of PHA manufacturing might be significantly increased by advancements in this area, as these processes now account for a significant amount of the total production cost. The systematic screening of various fruit waste products to determine which ha ve the greatest potential for PHA generation should be the main focus of future studies. Furthermore, improvements in genetic engineering and the optimization of the met a bolic pathways of microorganisms that produce PHA may increase production and lower expenses. This article presents a th o rough analysis of the value-adding of different kinds of fruit wastes for the production of biopolymers, stressing the various strategies used thus far, their drawbacks, and possible future development paths. The large-scale synthesis of PHAs from fruit waste may prove to be a sustainable and profitable way to lessen the environmental effects of conventional plastics by tackling current issues and utilizing cutting-edge technologies.References
Akdoğan, M., & Çelik, E. (2021). Enhanced production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) biopolymer by recombinant Bacillus megaterium in fed-batch bioreactors. Bioprocess and Biosystems Engineering, 44(2), 403–416.
Alkotaini, B., Abdellaoui, S., Hasan, K., Grattieri, M., Quah, T., Cai, R., Yuan, M., & Minteer, S. D. (2018). Sustainable bioelectrosynthesis of the bioplastic polyhydroxybutyrate: overcoming substrate requirement for NADH regeneration. ACS Sustainable Chemistry & Engineering, 6(4), 4909–4915.
Alsafadi, D., Ibrahim, M. I., Alamry, K. A., Hussein, M. A., & Mansour, A. (2020). Utilizing the crop waste of date palm fruit to biosynthesize polyhydroxyalkanoate bioplastics with favorable properties. Science of the Total Environment, 737, 139716.
Amaro, T. M., Rosa, D., Comi, G., & Iacumin, L. (2019). Prospects for the use of whey for polyhydroxyalkanoate (PHA) production. Frontiers in Microbiology, 10, 992.
An, X., Zhang, R., Liu, L., Yang, J., Tian, Z., Yang, G., Cao, H., Cheng, Z., Ni, Y., & Liu, H. (2022). Ozone pretreatment facilitating cellulase hydrolysis of unbleached bamboo pulp for improved fiber flexibility. Industrial Crops and Products, 178, 114577.
Andler, R., Pino, V., Moya, F., Soto, E., Valdés, C., & Andreeßen, C. (2021). Synthesis of poly-3-hydroxybutyrate (PHB) by Bacillus cereus using grape residues as sole carbon source. International Journal of Biobased Plastics, 3(1), 98–111.
Andler, R., Valdés, C., Urtuvia, V., Andreeßen, C., & Díaz-Barrera, A. (2021). Fruit residues as a sustainable feedstock for the production of bacterial polyhydroxyalkanoates. Journal of Cleaner Production, 307, 127236.
Antar, M., Lyu, D., Nazari, M., Shah, A., Zhou, X., & Smith, D. L. (2021). Biomass for a sustainable bioeconomy: An overview of world biomass production and utilization. Renewable and Sustainable Energy Reviews, 139, 110691.
Baidurah, S., Murugan, P., Sen, K. Y., Furuyama, Y., Nonome, M., Sudesh, K., & Ishida, Y. (2019). Evaluation of soil burial biodegradation behavior of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on the basis of change in copolymer composition monitored by thermally assisted hydrolysis and methylation – gas chromatography. Journal of Analytical and Applied Pyrolysis, 137, 146–150.
Basso, D., Weiss-Hortala, E., Patuzzi, F., Baratieri, M., & Fiori, L. (2018). In deep analysis on the behavior of grape marc constituents during hydrothermal carbonization. Energies, 11(6), 1379.
Behera, S., Priyadarshanee, M., & Das, S. (2022). Polyhydroxyalkanoates, the bioplastics of microbial origin: Properties, biochemical synthesis, and their applications. Chemosphere, 294, 133723.
Bhattacharjya, S., Das, S., & Amat, D. (2021). Potential of microbial inoculants for organic waste decomposition and decontamination. Biofertilizers, 1, 103–132.
Blunt, W., Lagassé, A., Jin, Z., Dartiailh, C., Sparling, R., Gapes, D. J., Levin, D. B., & Cicek, N. (2019). Efficacy of medium chain-length polyhydroxyalkanoate biosynthesis from different biochemical pathways under oxygen-limited conditions using Pseudomonas putida LS46. Process Biochemistry, 82, 19–31.
Blunt, W., Sparling, R., Gapes, D. J., Levin, D. B., & Cicek, N. (2018). The role of dissolved oxygen content as a modulator of microbial polyhydroxyalkanoate synthesis. World Journal of Microbiology and Biotechnology, 34(8), 106.
Boey, J. Y., Mohamad, L., Khok, Y. S., Tay, G. S., & Baidurah, S. (2021). A review of the applications and biodegradation of polyhydroxyalkanoates and poly (lactic acid) and its composites. Polymers, 13(10), 1544.
Bonartsev, A. P., Bonartseva, G. A., Reshetov, I. V., Kirpichnikov, M. P., & Shaitan, K. V. (2019). Application of polyhydroxyalkanoates in medicine and the biological activity of natural poly(3-hydroxybutyrate). Acta Naturae, 11(2), 4–16.
Bonfiglio, F., Cagno, M., Rey, F., Torres, M., Böthig, S., Menéndez, P., & Mussatto, S. I. (2019). Pretreatment of switchgrass by steam explosion in a semi-continuous pre-pilot reactor. Biomass and Bioenergy, 121, 41–47.
Boro, M., Verma, A. K., Chettri, D., Yata, V. K., & Verma, A. K. (2022). Strategies involved in biofuel production from agro-based lignocellulose biomass. Environmental Technology and Innovation, 2022, 102679.
Bychkov, A., Podgorbunskikh, E., Ryabchikova, E., & Lomovsky, O. (2018). The role of mechanical action in the process of the thermomechanical isolation of lignin. Cellulose, 25(1), 1–5.
Cai, J., He, Y., Yu, X., Banks, S. W., Yang, Y., Zhang, X., Yu, Y., Liu, R., & Bridgwater, A. V. (2017). Review of physicochemical properties and analytical characterization of lignocellulosic biomass. Renewable and Sustainable Energy Reviews, 76, 309–322.
Chavan, S., Yadav, B., Tyagi, R., Wong, J. W., & Drogui, P. (2023). Trends and challenges in the valorization of kitchen waste to polyhydroxyalkanoates. Bioresource Technology, 369, 128323.
Chen, F., Liu, X., Ge, X., Wang, Y., Zhao, Z., Zhang, X., Chen, G.-Q., & Sun, Y. (2023). Porous polydroxyalkanoates (PHA) scaffolds with antibacterial property for oral soft tissue regeneration. Chemical Engineering Journal, 451, 138899.
Chen, H., Liu, J., Chang, X., Chen, D., Xue, Y., Liu, P., Lin, H., & Han, S. (2017). A review on the pretreatment of lignocellulose for high-value chemicals. Fuel Processing Technology, 160, 196–206.
Chiranjeevi, T., Mattam, A. J., Vishwakarma, K. K., Uma, A., Peddy, V. R., Gandham, S., & Ravindra Velankar, H. (2018). Assisted single-step acid pretreatment process for enhanced delignification of rice straw for bioethanol production. ACS Sustainable Chemistry and Engineering, 6(7), 8762–8774.
Costa, P., Basaglia, M., Casella, S., & Favaro, L. (2022). Polyhydroxyalkanoate production from fruit and vegetable waste processing. Polymers, 14(24), 5529.
Costa, P., Basaglia, M., Casella, S., Kennes, C., Favaro, L., & Veiga, M. C. (2023). Autotrophic production of polyhydroxyalkanoates using acidogenic-derived H2 and CO2 from fruit waste. Bioresource Technology, 390, 129880.
Cruz, R. A. P., Oehmen, A., & Reis, M. A. M. (2022). The impact of biomass withdrawal strategy on the biomass selection and polyhydroxyalkanoates accumulation of mixed microbial cultures. New Biotechnology, 66, 8–15.
Dev, B., Zaky, A. S., & Jayabalan, R. (2019). Bioethanol fermentation: The path forward for eco-friendly and sustainable development. In: Dev, B., Zaky, A. S., & Jayabalan, R. Technologies for value addition in food products and processes. Apple Academic Press, Palm Bay. Pp. 233–270.
Dharmaraja, J., Shobana, S., Arvindnarayan, S., Francis, R. R., Jeyakumar, R. B., Saratale, R. G., Ashokkumar, V., Bhatia, S. K., Kumar, V., & Kumar, G. (2023). Lignocellulosic biomass conversion via greener pretreatment methods towards biorefinery applications. Bioresource Technology, 369, 128328.
Dietrich, K., Dumont, M.-J., Del Rio, L. F., & Orsat, V. (2017). Producing PHAs in the bioeconomy – towards a sustainable bioplastic. Sustainable Production and Consumption, 9, 58–70.
Dietrich, K., Dumont, M.-J., Orsat, V., & Del Rio, L. F. (2019). Consumption of sugars and inhibitors of softwood hemicellulose hydrolysates as carbon sources for polyhydroxybutyrate (PHB) production with Paraburkholderia sacchari IPT 101. Cellulose, 26(13), 7939–7952.
Dilkes-Hoffman, L. S., Lant, P. A., Laycock, B., & Pratt, S. (2019). The rate of biodegradation of PHA bioplastics in the marine environment: A meta-study. Marine Pollution Bulletin, 142, 15–24.
Follonier, S., Goyder, M. S., Silvestri, A.-C., Crelier, S., Kalman, F., Riesen, R., & Zinn, M. (2014). Fruit pomace and waste frying oil as sustainable resources for the bioproduction of medium-chain-length polyhydroxyalkanoates. International Journal of Biological Macromolecules, 71, 42–52.
Follonier, S., Riesen, R., & Zinn, M. (2015). Pilot-scale production of functionalized mcl-PHA from grape pomace supplemented with fatty acids. Chemical and Biochemical Engineering Quarterly, 29(2), 113–121.
Freitas, E. N. D., Salgado, J. C. S., Alnoch, R. C., Contato, A. G., Habermann, E., Michelin, M., Martínez, C. A., & Polizeli, M. D. L. (2021). Challenges of biomass utilization for bioenergy in a climate change scenario. Biology, 10(12), 1277.
Gao, Y., Liu, Y., & Zou, D. (2023) Microwave-assisted synthesis and environmental remediation: A review. Environmental Chemistry Letters, 21, 2399–2416.
Getachew, A., & Woldesenbet, F. (2016). Production of biodegradable plastic by polyhydroxybutyrate (PHB) accumulating bacteria using low cost agricultural waste material. BMC Research Notes, 9(1), 509.
Govil, T., Wang, J., Samanta, D., David, A., Tripathi, A., Rauniyar, S., Salem, D. R., & Sani, R. K. (2020). Lignocellulosic feedstock: A review of a sustainable platform for cleaner production of nature’s plastics. Journal of Cleaner Production, 270, 122521.
Gowda, V., & Shivakumar, S. (2014). Agrowaste-based polyhydroxyalkanoate (PHA) production using hydrolytic potential of Bacillus thuringiensis IAM 12077. Brazilian Archives of Biology and Technology, 57(1), 55–61.
Groh, K. J., Backhaus, T., Carney-Almroth, B., Geueke, B., Inostroza, P. A., Lennquist, A., Leslie, H. A., Maffini, M., Slunge, D., & Trasande, L. (2019). Overview of known plastic packaging-associated chemicals and their hazards. Science of the Total Environment, 651, 3253–3268.
Gu, B.-J., Wang, J., Wolcott, M. P., & Ganjyal, G. M. (2018). Increased sugar yield from pre-milled Douglas-fir forest residuals with lower energy consumption by using planetary ball milling. Bioresource Technology, 251, 93–98.
Hoang, A. T., Nizetic, S., Ong, H. C., Chong, C. T., & Atabani, A. (2021). Acid-based lignocellulosic biomass biorefinery for bioenergy production: Advantages, application constraints, and perspectives. Journal of Environmental Management, 296, 113194.
Huang, T.-Y., Duan, K.-J., Huang, S.-Y., & Chen, C. W. (2006). Production of polyhydroxyalkanoates from inexpensive extruded rice bran and starch by Haloferax mediterranei. Journal of Industrial Microbiology and Biotechnology, 33(8), 701–706.
Ilanidis, D., Stagge, S., Jönsson, L. J., & Martín, C. (2021). Hydrothermal pretreatment of wheat straw: Effects of temperature and acidity on byproduct formation and inhibition of enzymatic hydrolysis and ethanolic fermentation. Agronomy, 11(3), 487.
Irmak, S., Meryemoglu, B., Sandip, A., Subbiah, J., Mitchell, R. B., & Sarath, G. (2018). Microwave pretreatment effects on switchgrass and miscanthus solubilization in subcritical water and hydrolysate utilization for hydrogen production. Biomass and Bioenergy, 108, 48–54.
John, I., Pola, J., Muthukumar, K., Thanabalan, M., & Appusamy, A. (2022). Production of bioethanol from sweet lime peel via a statistically optimized simultaneous saccharification and fermentation process using isolated enzymes. Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, 44(1), 1327–1335.
Joy, S. P., & Krishnan, C. (2022). Modified organosolv pretreatment for improved cellulosic ethanol production from sorghum biomass. Industrial Crops and Products, 177, 114409.
Kalia, V. C., Patel, S. K., & Lee, J.-K. (2023). Exploiting polyhydroxyalkanoates for biomedical applications. Polymers, 15(8), 1937.
Kaur, M. (2022). Effect of particle size on enhancement of biogas production from crop residue. Materials Today: Proceedings, 57, 1950–1954.
Kaushik, P. K., Reymond, D. J., Subha, C., & Lawrance, V. (2023). Review on biocrude generated from plastic waste using pyrolysis process. AIP Conference Proceedings, 2852(1), 130010.
Khatami, K., Perez-Zabaleta, M., Owusu-Agyeman, I., & Cetecioglu, Z. (2021). Waste to bioplastics: How close are we to sustainable polyhydroxyalkanoates production? Waste Management, 119, 374–388.
Khorshidian, N., Yousefi, M., & Khosravi-Darani, K. (2022). Valorization of date waste using microbial fermentations. Biomass Conversion and Biorefinery, 14(21), 26597–26610.
Koh, J. J., Zhang, X., & He, C. (2018). Fully biodegradable poly (lactic acid)/ starch blends: A review of toughening strategies. International Journal of Biological Macromolecules, 109, 99–113.
Koller, M. (2019). Polyhydroxyalkanoate biosynthesis at the edge of water activity – Haloarchaea as biopolyester factories. Bioengineering, 6(2), 34.
Koller, M., Maršálek, L., de Sousa Dias, M. M., & Braunegg, G. (2017). Producing microbial polyhydroxyalkanoate (PHA) biopolyesters in a sustainable manner. New Biotechnology, 37, 24–38.
Kostas, E. T., Beneroso, D., & Robinson, J. P. (2017). The application of microwave heating in bioenergy: A review on the microwave pre-treatment and upgrading technologies for biomass. Renewable and Sustainable Energy Reviews, 77, 12–27.
Kourilova, X., Pernicova, I., Vidlakova, M., Krejcirik, R., Mrazova, K., Hrubanova, K., Krzyzanek, V., Nebesarova, J., & Obruca, S. (2021). Biotechnological conversion of grape pomace to poly (3-hydroxybutyrate) by moderately thermophilic bacterium Tepidimonas taiwanensis. Bioengineering, 8(10), 141.
Kourmentza, C., Costa, J., Azevedo, Z., Servin, C., Grandfils, C., De Freitas, V., & Reis, M. (2018). Burkholderia thailandensis as a microbial cell factory for the bioconversion of used cooking oil to polyhydroxyalkanoates and rhamnolipids. Bioresource Technology, 247, 829–837.
Kourmentza, C., Plácido, J., Venetsaneas, N., Burniol-Figols, A., Varrone, C., Gavala, H. N., & Reis, M. A. (2017). Recent advances and challenges towards sustainable polyhydroxyalkanoate (PHA) production. Bioengineering, 4(2), 55.
Kovalcik, A., Pernicova, I., Obruca, S., Szotkowski, M., Enev, V., Kalina, M., & Marova, I. (2020). Grape winery waste as a promising feedstock for the production of polyhydroxyalkanoates and other value-added products. Food and Bioproducts Processing, 124, 1–10.
Kulkarni, S., Kanekar, P., Jog, J., Sarnaik, S., & Nilegaonkar, S. (2015). Production of copolymer, poly (hydroxybutyrate-co-hydroxyvalerate) by Halomonas campisalis MCM B-1027 using agro-wastes. International Journal of Biological Macromolecules, 72, 784–789.
Kumar, H., Bhardwaj, K., Sharma, R., Nepovimova, E., Kuča, K., Dhanjal, D. S., Verma, R., Bhardwaj, P., Sharma, S., & Kumar, D. (2020). Fruit and vegetable peels: Utilization of high value horticultural waste in novel industrial applications. Molecules, 25(12), 2812.
Kumar, M., Singhal, A., Verma, P. K., & Thakur, I. S. (2017). Production and characterization of polyhydroxyalkanoate from lignin derivatives by Pandoraea sp. ISTKB. ACS Omega, 2(12), 9156–9163.
Kumari, D., & Singh, R. (2018). Pretreatment of lignocellulosic wastes for biofuel production: A critical review. Renewable and Sustainable Energy Reviews, 90, 877–891.
Liguori, R., & Faraco, V. (2016). Biological processes for advancing lignocellulosic waste biorefinery by advocating circular economy. Bioresource Technology, 215, 13–20.
Low, T. J., Mohammad, S., Sudesh, K., & Baidurah, S. (2021). Utilization of banana (Musa sp.) fronds extract as an alternative carbon source for poly (3-hydroxybutyrate) production by Cupriavidus necator H16. Biocatalysis and Agricultural Biotechnology, 34, 102048.
Luo, X., Zeng, B., Zhong, Y., & Chen, J. (2022). Production and detoxification of inhibitors during the destruction of lignocellulose spatial structure. BioResources, 17(1), 1939–1961.
Luzón-Quintana, L. M., Castro, R., & Durán-Guerrero, E. (2021). Biotechnological processes in fruit vinegar production. Foods, 10(5), 945.
Mahjoub, B., & Domscheit, E. (2020). Chances and challenges of an organic waste-based bioeconomy. Current Opinion in Green and Sustainable Chemistry, 25, 100388.
Maqbool, Z., Khalid, W., Atiq, H. T., Koraqi, H., Javaid, Z., Alhag, S. K., Al-Shuraym, L. A., Bader, D. M. D., Almarzuq, M., Afifi, M., & Al-Farga, A. (2023). Citrus waste as source of bioactive compounds: Extraction and utilization in health and food industry. Molecules, 28(4), 1636.
Meereboer, K. W., Misra, M., & Mohanty, A. K. (2020). Review of recent advances in the biodegradability of polyhydroxyalkanoate (PHA) bioplastics and their composites. Green Chemistry, 22(17), 5519–5558.
Moro, M. K., Teixeira, R. S. S., da Silva, A. S. A., Fujimoto, M. D., Melo, P. A., Secchi, A. R., & da Silva Bon, E. P. (2017). Continuous pretreatment of sugarcane biomass using a twin-screw extruder. Industrial Crops and Products, 97, 509–517.
Mouhoubi, R., Lasschuijt, M., Carrasco, S. R., Gojzewski, H., & Wurm, F. R. (2022). End-of-life biodegradation? How to assess the composting of polyesters in the lab and the field. Waste Management, 154, 36–48.
Muneer, F., Rasul, I., Azeem, F., Siddique, M. H., Zubair, M., & Nadeem, H. (2020). Microbial polyhydroxyalkanoates (PHAs): Efficient replacement of synthetic polymers. Journal of Polymers and the Environment, 28, 2301–2323.
Muthuraj, R., Valerio, O., & Mekonnen, T. H. (2021). Recent developments in short-and medium-chain-length polyhydroxyalkanoates: Production, properties, and applications. International Journal of Biological Macromolecules, 187, 422–440.
Nahar, S., Jeong, M.-H., & Hur, J.-S. (2019). Lichen-associated bacterium, a novel bioresource of polyhydroxyalkanoate (PHA) production and simultaneous degradation of naphthalene and anthracene. Journal of Microbiology and Biotechnology, 29(1), 79–90.
Naranjo, M. C., Redondo, A. E., Acuña, J. C., Vieira, N. S., Araújo, J. M., & Pereiro, A. B. (2022). Synthesis and characterization of fluorinated phosphonium ionic liquids to use as new engineering solvents. ChemEngineering, 6(3), 38.
Narayanan, A., Sajeev Kumar, V., & Ramana, K. V. (2014). Production and characterization of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) from Bacillus mycoides DFC1 using rice husk hydrolyzate. Waste and Biomass Valorization, 5(1), 109–118.
Nargotra, P., Sharma, V., Gupta, M., Kour, S., & Bajaj, B. K. (2018). Application of ionic liquid and alkali pretreatment for enhancing saccharification of sunflower stalk biomass for potential biofuel-ethanol production. Bioresource Technology, 267, 560–568.
Neifar, M., Naili, F., & Chouchane, H. (2018). Potential use of microbial thermo-bioplastic polyhydroxyalkanoate as promising tissue engineering biomaterial in biomedicine. Tissue Engineering and Regenerative Medicine, 4(2), 34–37.
Østby, H., Hansen, L. D., Horn, S. J., Eijsink, V. G., & Várnai, A. (2020). Enzymatic processing of lignocellulosic biomass: Principles, recent advances and perspectives. Journal of Industrial Microbiology and Biotechnology, 47(9–10), 623–657.
Ouyang, X., Chen, L., Zhang, S., Yuan, Q., Wang, W., & Linhardt, L. (2018). Effect of simultaneous steam explosion and alkaline depolymerization on corncob lignin and cellulose structure. Chemical and Biochemical Engineering Quarterly, 32(2), 177–189.
Pais, J., Serafim, L. S., Freitas, F., & Reis, M. A. (2016). Conversion of cheese whey into poly (3-hydroxybutyrate-co-3-hydroxyvalerate) by Haloferax mediterranei. New Biotechnology, 33(1), 224–230.
Pan, W., Perrotta, J. A., Stipanovic, A. J., Nomura, C. T., & Nakas, J. P. (2012). Production of polyhydroxyalkanoates by Burkholderia cepacia ATCC 17759 using a detoxified sugar maple hemicellulosic hydrolysate. Journal of Industrial Microbiology and Biotechnology, 39(3), 459–469.
Pandey, R., Nahar, N., Tumuluru, J. S., & Pryor, S. W. (2019). Quantifying reductions in soaking in aqueous ammonia pretreatment severity and enzymatic hydrolysis conditions for corn stover pellets. Bioresource Technology Reports, 7, 100187.
Pereira, J. R., Araújo, D., Freitas, P., Marques, A. C., Alves, V. D., Sevrin, C., Grandfils, C., Fortunato, E., Reis, M. A., & Freitas, F. (2021). Production of medium-chain-length polyhydroxyalkanoates by Pseudomonas chlororaphis subsp. aurantiaca: Cultivation on fruit pulp waste and polymer characterization. International Journal of Biological Macromolecules, 167, 85–92.
Pérez-Rodríguez, N., Garcia-Bernet, D., & Domínguez, J. (2018). Faster methane production after sequential extrusion and enzymatic hydrolysis of vine trimming shoots. Environmental Chemistry Letters, 16(1), 295–299.
Periyasamy, S., Karthik, V., Senthil Kumar, P., Isabel, J. B., Temesgen, T., Hunegnaw, B., Melese, B., Mohamed, B. A., & Vo, D.-V. N. (2022). Chemical, physical and biological methods to convert lignocellulosic waste into value-added products. A review. Environmental Chemistry Letters, 20(2), 1129–1152.
Pramanik, N. (2023). A tool for biomedical application: Synthesis and modification of polyhydroxyalkanoates. Sustainable Chemistry and Pharmacy, 32, 101041.
Pryadko, A., Surmeneva, M. A., & Surmenev, R. A. (2021). Review of hybrid materials based on polyhydroxyalkanoates for tissue engineering applications. Polymers, 13(11), 1738.
Qiao, W., Dong, G., Xu, S., Li, L., & Shi, S. (2023). Engineering propionyl-CoA pools for de novo biosynthesis of odd-chain fatty acids in microbial cell factories. Critical Reviews in Biotechnology, 43(7), 1063–1072.
Ranganadhareddy, A., & Chandrsekhar, C. (2022). Polyhydroxyalkanoates, the biopolymers of microbial origin – a review. Journal of Biochemical Technology, 13(3), 1–6.
Ranganathan, S., Dutta, S., Moses, J., & Anandharamakrishnan, C. (2020). Utilization of food waste streams for the production of biopolymers. Heliyon, 6(9), e04891.
Rao, A., Haque, S., El-Enshasy, H. A., Singh, V., & Mishra, B. N. (2019). RSM-GA based optimization of bacterial PHA production and in silico modulation of citrate synthase for enhancing PHA production. Biomolecules, 9(12), 872.
Rayasam, V., Chavan, P., & Kumar, T. (2020). Polyhydroxyalkanoate synthesis by bacteria isolated from landfill and ETP with pomegranate peels as carbon source. Archives of Microbiology, 202(10), 2799–2808.
Raza, Z. A., Abid, S., & Banat, I. M. (2018). Polyhydroxyalkanoates: Characteristics, production, recent developments and applications. International Biodeterioration and Biodegradation, 126, 45–56.
Rebocho, A. T., Pereira, J. R., Freitas, F., Neves, L. A., Alves, V. D., Sevrin, C., Grandfils, C., & Reis, M. A. (2019). Production of medium-chain length polyhydroxyalkanoates by Pseudomonas citronellolis grown in apple pulp waste. Applied Food Biotechnology, 6(1), 71–82.
Rebocho, A. T., Pereira, J. R., Neves, L. A., Alves, V. D., Sevrin, C., Grandfils, C., Freitas, F., & Reis, M. A. (2020). Preparation and characterization of films based on a natural p (3hb)/mcl-pha blend obtained through the co-culture of cupriavidus necator and pseudomonas citronellolis in apple pulp waste. Bioengineering, 7(2), 34.
Riedel, S. L., & Brigham, C. J. (2020). Inexpensive and waste raw materials for PHA production. In: Koller, M. (Ed.). The handbook of polyhydroxyalkanoates. CRC Press, Taylor & Francis, Boca Raton. Pp. 203–221.
Ruiz, C., Kenny, S. T., Narancic, T., Babu, R., & O’Connor, K. (2019). Conversion of waste cooking oil into medium chain polyhydroxyalkanoates in a high cell density fermentation. Journal of Biotechnology, 306, 9–15.
Salomez, M., George, M., Fabre, P., Touchaleaume, F., Cesar, G., Lajarrige, A., & Gastaldi, E. (2019). A comparative study of degradation mechanisms of PHBV and PBSA under laboratory – scale composting conditions. Polymer Degradation and Stability, 167, 102–113.
Sangkharak, K., Khaithongkaeo, P., Chuaikhunupakarn, T., Choonut, A., & Prasertsan, P. (2021). The production of polyhydroxyalkanoate from waste cooking oil and its application in biofuel production. Biomass Conversion and Biorefinery, 11(5), 1651–1664.
Sathesh, P. C., & Murugesan, A. (2010). Effective utilization and management of coir industrial waste for the production of poly-β-hydroxybutyrate (PHB) using the bacterium Azotobacter beijerinickii. International Journal of Environmental Research, 4(3), 519–524.
Sawant, S. S., Salunke, B. K., & Kim, B. S. (2015). Degradation of corn stover by fungal cellulase cocktail for production of polyhydroxyalkanoates by moderate halophile Paracoccus sp. LL1. Bioresource Technology, 194, 247–255.
Sedničková, M., Pekařová, S., Kucharczyk, P., Bočkaj, J., Janigová, I., Kleinová, A., Jochec-Mošková, D., Omaníková, L., Perďochová, D., & Koutný, M. (2018). Changes of physical properties of PLA-based blends during early stage of biodegradation in compost. International Journal of Biological Macromolecules, 113, 434–442.
Selvakumar, P., & Sivashanmugam, P. (2020). Studies on the extraction of polyphenolic compounds from pre-consumer organic solid waste. Journal of Industrial and Engineering Chemistry, 82, 130–137.
Sharma, M., & Dhingra, H. K. (2021). An overview of microbial derived polyhydroxybutyrate (PHB): Production and characterization. In: Vaishnav, A., & Choudhary, D. K. (Eds.). Microbial polymers. Springer, Singapore. Pp. 143–176.
Sharma, V., Sehgal, R., & Gupta, R. (2021). Polyhydroxyalkanoate (PHA): Properties and modifications. Polymer, 212, 123161.
Sheldon, R. A., & Norton, M. (2020). Green chemistry and the plastic pollution challenge: Towards a circular economy. Green Chemistry, 22(19), 6310–6322.
Sindhu, R., Binod, P., & Pandey, A. (2016). Biological pretreatment of lignocellulosic biomass – An overview. Bioresource Technology, 199, 76–82.
Soni, S. K., Sharma, A., & Soni, R. (2023). Microbial enzyme systems in the production of second generation bioethanol. Sustainability, 15(4), 3590.
Sousa, E. C., Uchôa-Thomaz, A. M. A., Carioca, J. O. B., Morais, S. M. D., Lima, A. D., Martins, C. G., Alexandrino, C. D., Ferreira, P. A. T., Rodrigues, A. L. M., & Rodrigues, S. P. (2014). Chemical composition and bioactive compounds of grape pomace (Vitis vinifera L.), Benitaka variety, grown in the semiarid region of Northeast Brazil. Food Science and Technology, 34(1), 135–142.
Sukan, A., Roy, I., & Keshavarz, T. (2014). Agro-industrial waste materials as substrates for the production of poly (3-hydroxybutyric acid). Journal of Biomaterials and Nanobiotechnology, 5(4), 229–240.
Sukruansuwan, V., & Napathorn, S. C. (2018). Use of agro-industrial residue from the canned pineapple industry for polyhydroxybutyrate production by Cupriavidus necator strain A-04. Biotechnology for Biofuels, 11(1), 202.
Sun, J., Konda, N. M., Parthasarathi, R., Dutta, T., Valiev, M., Xu, F., Simmons, B. A., & Singh, S. (2017). One-pot integrated biofuel production using low-cost biocompatible protic ionic liquids. Green Chemistry, 19(13), 3152–3163.
Suwannasing, W., Imai, T., & Kaewkannetra, P. (2015). Cost-effective defined medium for the production of polyhydroxyalkanoates using agricultural raw materials. Bioresource Technology, 194, 67–74.
Tolesa, L. D., Gupta, B. S., & Lee, M.-J. (2018). Treatment of coffee husk with ammonium-based ionic liquids: Lignin extraction, degradation, and characterization. ACS Omega, 3(9), 10866–10876.
Tripathi, A. D., Mishra, P. K., Darani, K. K., Agarwal, A., & Paul, V. (2022). Hydrothermal treatment of lignocellulose waste for the production of polyhydroxyalkanoates copolymer with potential application in food packaging. Trends in Food Science and Technology, 123, 233–250.
Valdez-Calderón, A., Barraza-Salas, M., Quezada-Cruz, M., Islas-Ponce, M., Angeles-Padilla, A., Carrillo-Ibarra, S., Rodríguez, M., Rojas-Avelizapa, N., Garrido-Hernández, A., & Rivas-Castillo, A. (2022). Production of polyhydroxybutyrate (PHB) by a novel Klebsiella pneumoniae strain using low-cost media from fruit peel residues. Biomass Conversion and Biorefinery, 12(11), 4925–4938.
Vega-Castro, O., Contreras-Calderon, J., León, E., Segura, A., Arias, M., Pérez, L., & Sobral, P. J. (2016). Characterization of a polyhydroxyalkanoate obtained from pineapple peel waste using Ralsthonia eutropha. Journal of Biotechnology, 231, 232–238.
Vicente, D., Proença, D. N., & Morais, P. V. (2023). The role of bacterial polyhydroalkanoate (PHA) in a sustainable future: a review on the biological diversity. International Journal of Environmental Research and Public Health, 20(4), 2959.
Vigneri, R., Malandrino, P., Gianì, F., Russo, M., & Vigneri, P. (2017). Heavy metals in the volcanic environment and thyroid cancer. Molecular and Cellular Endocrinology, 457, 73–80.
Volova, T. G., Kiselev, E. G., Demidenko, A. V., Zhila, N. O., Nemtsev, I. V., & Lukyanenko, A. V. (2021). Production and properties of microbial polyhydroxyalkanoates synthesized from hydrolysates of Jerusalem artichoke tubers and vegetative biomass. Polymers, 14(1), 132.
Volova, T., Kiselev, E., Nemtsev, I., Lukyanenko, А., Sukovatyi, A., Kuzmin, A., Ryltseva, G., & Shishatskaya, E. (2021). Properties of degradable polyhydroxyalkanoates with different monomer compositions. International Journal of Biological Macromolecules, 182, 98–114.
Yan, Q., Cordell, W. T., Jindra, M. A., Courtney, D. K., Kuckuk, M. K., Chen, X., & Pfleger, B. F. (2022). Metabolic engineering strategies to produce medium-chain oleochemicals via acyl-ACP: CoA transacylase activity. Nature Communications, 13(1), 1619.
Yu, X., Zhao, Y., Yu, J., & Wang, L. (2023). Recent advances in the efficient degradation of lignocellulosic metabolic networks by lytic polysaccharide monooxygenase: Advancing lignocellulose degradation with LPMOs. Acta Biochimica et Biophysica Sinica, 55(4), 529–539.
Yuan, S., Wu, Y., & Cosgrove, D. J. (2001). A fungal endoglucanase with plant cell wall extension activity. Plant Physiology, 127(1), 324–333.
Zema, D., Calabrò, P., Folino, A., Tamburino, V., Zappia, G., & Zimbone, S. (2018). Valorisation of citrus processing waste: A review. Waste Management, 80, 252–273.
Zhai, R., Hu, J., & Jin, M. (2022). Towards efficient enzymatic saccharification of pretreated lignocellulose: Enzyme inhibition by lignin-derived phenolics and recent trends in mitigation strategies. Biotechnology Advances, 61, 108044.
Zhao, C., Shao, Q., & Chundawat, S. P. (2020). Recent advances on ammonia-based pretreatments of lignocellulosic biomass. Bioresource Technology, 298, 122446.
Zhao, S., Danley, M., Ward, J. E., Li, D., & Mincer, T. J. (2017). An approach for extraction, characterization and quantitation of microplastic in natural marine snow using Raman microscopy. Analytical Methods, 9(9), 1470–1478.
Zytner, P., Pal, A. K., Wu, F., Rodriguez-Uribe, A., Mohanty, A. K., & Misra, M. (2023). Morphology and performance relationship studies on poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (butylene adipate-co-terephthalate)-based biodegradable blends. ACS Omega, 8(2), 1946–1956.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons «Attribution» 4.0 License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.


