Metabolism of calcidiol and calcium in pregnant and lactating goats
Abstract
The aim of our study was to investigate the dynamics of the metabolism of one of the active metabolites of vitamin D – 25OHD 3 and its effect on the metabolism of total and ionized calcium in pregnant and lactating goats. The subject of the study was Z aanen and L aman goats: pregnant (75–90 and 120–140 days of pregnancy) and lactating animals (0–2 and 15–25 days after ki d ding). The content of 25OHD 3 in the blood serum of goats was in the range of 9.8–54.2 ng/mL, including 10.4–32.4 ng/mL in the pregnant animals (75–140 days) and 9.8–54.2 ng/mL in the lactating animals (0–25 days). The dynamics of calcidiol in the blood serum of the pregnant goats was characterised by a 1.35 - fold increase in its concentration on the 120–140th day s compared to the animals 75–90 days of kidding, with maximum values on the 0–2nd day s after kidding and a decrease in its content on the 15–25th day s of lactation. In clinically healthy goats with optimal serum calcium content, the total concentration of 25OHD 3 ranged from 10.4 to 54.2 ng/mL, including 10.4–32.4 ng/mL in the pregnant animals and 12.1–54.2 ng/mL in the lactating animals. In the su b clinical course of hypocalcaemia, the serum calcidiol content in the blood of goats was in the range of 9.8–29.8 ng/mL, including in pregnant animals – from 11.0 to 21.0 ng/mL, during the first 15–25 th days of lactation – 9.8–29.8 ng/mL. At the optimal content of ionised calcium in the blood serum of goats, the concentration of calcidiol was in the range of 10.4–54.2 ng/mL, against 9.8–29.8 ng/mL in animals with hypocalcaemia. There is a positive correlation between the values of 25OHD3 and total calcium in the blood serum of goats with subclinical hypocalcaemia.References
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